Journal article
Serologic Evidence of Avian Metapneumovirus Infection Among Adults Occupationally Exposed to Turkeys
Vector borne and zoonotic diseases (Larchmont, N.Y.), Vol.11(11), pp.1453-1458
11/01/2011
DOI: 10.1089/vbz.2011.0637
PMID: 21736487
Abstract
Genetically similar, the avian metapneumovirus (aMPV) and the human MPV (hMPV) are the only viruses in the
Metapneumovirus
genus. Previous research demonstrated the ability of hMPV to cause clinical disease in turkeys. In this controlled, cross-sectional, seroepidemiological study, we examined the hypothesis that aMPV might infect humans. We enrolled 95 adults occupationally exposed to turkeys and 82 nonexposed controls. Sera from study participants were examined for antibodies against aMPV and hMPV. Both in bivariate (OR=3.2; 95% CI: 1.1–9.2) and in multivariate modelling adjusting for antibody to hMPV (OR=4.1; 95% CI: 1.3–13.1), meat-processing workers were found to have an increased odds of previous infection with aMPV compared to controls. While hMPV antibody cross-reactivity is evident, these data suggest that occupational exposure to turkeys is a risk factor for human infection with aMPV. More studies are needed to validate these findings, to identify modes of aMPV transmission, and to determine risk factors associated with infection.
Details
- Title: Subtitle
- Serologic Evidence of Avian Metapneumovirus Infection Among Adults Occupationally Exposed to Turkeys
- Creators
- Ghazi Kayali - 1Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TennesseeErnesto J Ortiz - 2Emerging Infections Program, U.S. Naval Medical Research Center Detachment, Lima, PeruMargaret L Chorazy - 3Department of Epidemiology, University of Iowa, Iowa City, IowaKakambi V Nagaraja - 4Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MinnesotaJennifer DeBeauchamp - 1Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TennesseeRichard J Webby - 1Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TennesseeGregory C Gray - 5Department of Environmental and Global Health, University of Florida, Gainesville, Florida
- Resource Type
- Journal article
- Publication Details
- Vector borne and zoonotic diseases (Larchmont, N.Y.), Vol.11(11), pp.1453-1458
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/vbz.2011.0637
- PMID
- 21736487
- ISSN
- 1530-3667
- eISSN
- 1557-7759
- Language
- English
- Date published
- 11/01/2011
- Academic Unit
- Public Health Administration; Epidemiology
- Record Identifier
- 9983995159802771
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