Journal article
Serologic Testing for Celiac Disease in the United States: Results of a Multilaboratory Comparison Study
Clinical and diagnostic laboratory immunology, Vol.7(4), pp.584-587
07/2000
DOI: 10.1128/CDLI.7.4.584-587.2000
PMCID: PMC95918
PMID: 10882656
Abstract
The aim of this study was to compare the efficiencies of six reference laboratories for serologic testing for celiac disease. Serum from 20 patients with untreated celiac disease and from 20 controls was thawed, divided, and distributed to each participating laboratory, which performed endomysial antibody tests. Five laboratories also performed antigliadin antibody tests. Sensitivity for endomysial antibody immunoglobulin A (IgA) varied from 57 to 90%. In all laboratories, the specificity for celiac disease was 100%. The sensitivity and specificity for both IgA and IgG antigliadin antibody varied significantly. When results from all three tests were combined in each laboratory, sensitivity was 90 to 100%. The specificity for endomysial antibody was 100% in the laboratories. Sensitivity was less than reported previously. Standardization of these tests is needed in the United States.
Details
- Title: Subtitle
- Serologic Testing for Celiac Disease in the United States: Results of a Multilaboratory Comparison Study
- Creators
- Joseph A Murray - Departments of Internal MedicineJudith Herlein - Departments of Internal MedicineFrank Mitros - Departments of Internal MedicineJames A Goeken - Departments of Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Clinical and diagnostic laboratory immunology, Vol.7(4), pp.584-587
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/CDLI.7.4.584-587.2000
- PMID
- 10882656
- PMCID
- PMC95918
- ISSN
- 1071-412X
- eISSN
- 1098-6588
- Language
- English
- Date published
- 07/2000
- Academic Unit
- Pathology
- Record Identifier
- 9984203946602771
Metrics
3 Record Views