Serological markers of hepatitis A, B and C viruses in Rural communities of the semiarid Brazilian Northeast

Delvone Almeida; José Tavares-Neto; Ludmila Vitvitski; Alessandro Almeida; Caroline Mello; Diana Santana; Fernando Tatsch; Raymundo Paraná

doi:10.1590/S1413-86702006000500003

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Serological markers of hepatitis A, B and C viruses in Rural communities of the semiarid Brazilian Northeast

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Serological markers of hepatitis A, B and C viruses in Rural communities of the semiarid Brazilian Northeast

Delvone Almeida, José Tavares-Neto, Ludmila Vitvitski, Alessandro Almeida, Caroline Mello, Diana Santana, Fernando Tatsch and Raymundo Paraná

The Brazilian journal of infectious diseases, Vol.10(5), pp.317-321

10/2006

DOI: 10.1590/S1413-86702006000500003

PMID: 17293918

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Abstract

In the village of Cavunge, located in a dry tropical, semiarid rural region of the state of Bahia, Brazil, a sentinel study on viral hepatitis is underway. We report on the first part of the study. The objective of this study was to determine the prevalence of serological markers for hepatitis A, B and C in the village. Cross sectional study. Blood samples were tested for serological markers of hepatitis A (HAV), B (HBV) and C (HCV) through ELISA-III assay. In HBsAg and anti-HCV carriers, HCV-RNA and HBV-DNA were checked by PCR. The prevalence of anti-HAV IgG was 83.3% (1,210/1,452), being higher among residents from the village (87.4%) than in residents from the rural area (79.5%); it also higher among individuals older than 10 years of age. The prevalence of HBsAg was 2.6% (38/1,476), 9.3% anti-HBc (137/1,476) and 10.5% (155/1,476) anti-HBs of. In more than half (58.1%; 90/155) of anti-HBs carriers, this was the only serological marker found. In 3.7% of the population, (55/1,476), anti-HBc was the only serological marker found. All HBV carriers were infected by genotype A. Only 0.4% (6/1,536) presented anti-HCV antibodies and only one of them was viremic, being infected with genotype 1. The prevalence of patients with antibodies against hepatitis A virus in the village of Cavunge was high, but the prevalence of B virus was moderate, with only genotype A among HBV carriers. The prevalence of C virus was very low, contrasting with the situation in large Brazilian urban centers.

Brazil

Epidemiology

Hepatitis A

Hepatitis B

Hepatitis C

Details

Title: Subtitle: Serological markers of hepatitis A, B and C viruses in Rural communities of the semiarid Brazilian Northeast
Creators: Delvone Almeida - Universidade do Estado da Bahia
José Tavares-Neto - Universidade do Estado da Bahia
Ludmila Vitvitski - Inserm
Alessandro Almeida - Universidade do Estado da Bahia
Caroline Mello - Universidade do Estado da Bahia
Diana Santana - Universidade do Estado da Bahia
Fernando Tatsch - Roche-Brazil Hepatitis Team, Brazil
Raymundo Paraná - Universidade Federal do Recôncavo da Bahia
Resource Type: Journal article
Publication Details: The Brazilian journal of infectious diseases, Vol.10(5), pp.317-321
DOI: 10.1590/S1413-86702006000500003
PMID: 17293918
NLM abbreviation: Braz J Infect Dis
ISSN: 1413-8670
eISSN: 1413-8670
Number of pages: 5
Language: English
Date published: 10/2006
Academic Unit: Radiology
Record Identifier: 9985134036302771

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