Journal article
Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease
Pharmacological research, Vol.203, 107171
05/2024
DOI: 10.1016/j.phrs.2024.107171
PMCID: PMC11088857
PMID: 38599469
Abstract
The impact of Alzheimer's disease (AD) and its related dementias is rapidly expanding, and its mitigation remains an urgent social and technical challenge. To date there are no effective treatments or interventions for AD, but recent studies suggest that alcohol consumption is correlated with the risk of developing dementia. In this review, we synthesize data from preclinical, clinical, and epidemiological models to evaluate the combined role of alcohol consumption and serotonergic dysfunction in AD, underscoring the need for further research on this topic. We first discuss the limitations inherent to current data-collection methods, and how neuropsychiatric symptoms common among AD, alcohol use disorder, and serotonergic dysfunction may mask their co-occurrence. We additionally describe how excess alcohol consumption may accelerate the development of AD via direct effects on serotonergic function, and we explore the roles of neuroinflammation and proteostasis in mediating the relationship between serotonin, alcohol consumption, and AD. Lastly, we argue for a shift in current research to disentangle the pathogenic effects of alcohol on early-affected brainstem structures in AD.
Details
- Title: Subtitle
- Serotonergic dysfunction may mediate the relationship between alcohol consumption and Alzheimer's disease
- Creators
- Samantha R Pierson - University of IowaLouis J Kolling - University of IowaThomas D James - University of IowaSelvakumar Govindhasamy Pushpavathi - University of IowaCatherine A Marcinkiewcz - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmacological research, Vol.203, 107171
- DOI
- 10.1016/j.phrs.2024.107171
- PMID
- 38599469
- PMCID
- PMC11088857
- ISSN
- 1043-6618
- eISSN
- 1096-1186
- Grant note
- DOI: 10.13039/100000049, name: National Institute on Aging, award: R01 AG070841; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: R01 AA028931
- Language
- English
- Date published
- 05/2024
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984585057002771
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