Journal article
Serotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.282(3), pp.R837-R841
03/01/2002
DOI: 10.1152/ajpregu.00311.2001
PMID: 11832405
Abstract
Central cholinergic mechanisms are suggested to participate in osmoreceptor-induced water intake. Therefore, central injections of the cholinergic agonist carbachol usually produce water intake (i.e., thirst) and are ineffective in inducing the intake of hypertonic saline solutions (i.e., the operational definition of sodium appetite). Recent studies have indicated that bilateral injections of the serotonin receptor antagonist methysergide into the lateral parabrachial nucleus (LPBN) markedly increases salt intake in models involving the activation of the renin-angiotensin system or mineralocorticoid hormones. The present studies investigated whether sodium appetite could be induced by central cholinergic activation with carbachol (an experimental condition where only water is typically ingested) after the blockade of LPBN serotonergic mechanisms with methysergide treatment in rats. When administered intracerebroventricularly in combination with injections of vehicle into both LPBN, carbachol (4 nmol) caused water drinking but insignificant intake of hypertonic saline. In contrast, after bilateral LPBN injections of methysergide (4 μg), intracerebroventricular carbachol induced the intake of 0.3 M NaCl. Water intake stimulated by intracerebroventricular carbachol was not changed by LPBN methysergide injections. The results indicate that central cholinergic activation can induce marked intake of hypertonic NaCl if the inhibitory serotonergic mechanisms of the LPBN are attenuated.
Details
- Title: Subtitle
- Serotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite
- Creators
- José Vanderlei Menani - Departments of Psychology, Pharmacology, and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and Department of Physiology and Pathology, School of Dentistry, Paulista State University, Araraquara, Sao Paulo 14801-903, BrazilSilas Pereira Barbosa - Departments of Psychology, Pharmacology, and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and Department of Physiology and Pathology, School of Dentistry, Paulista State University, Araraquara, Sao Paulo 14801-903, BrazilLaurival Antonio De Luca - Departments of Psychology, Pharmacology, and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and Department of Physiology and Pathology, School of Dentistry, Paulista State University, Araraquara, Sao Paulo 14801-903, BrazilJuliana Irani Fratucci De Gobbi - Departments of Psychology, Pharmacology, and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and Department of Physiology and Pathology, School of Dentistry, Paulista State University, Araraquara, Sao Paulo 14801-903, BrazilAlan Kim Johnson - Departments of Psychology, Pharmacology, and Exercise Science and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and Department of Physiology and Pathology, School of Dentistry, Paulista State University, Araraquara, Sao Paulo 14801-903, Brazil
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.282(3), pp.R837-R841
- DOI
- 10.1152/ajpregu.00311.2001
- PMID
- 11832405
- NLM abbreviation
- Am J Physiol Regul Integr Comp Physiol
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 03/01/2002
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213279802771
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