Journal article
Serotonin and sudden unexpected death in epilepsy
Experimental neurology, Vol.325, pp.113145-113145
03/2020
DOI: 10.1016/j.expneurol.2019.113145
PMID: 31866464
Abstract
Epilepsy is a highly prevalent disease characterized by recurrent, spontaneous seizures. Approximately one-third of epilepsy patients will not achieve seizure freedom with medical management and become refractory to conventional treatments. These patients are at greatest risk for sudden unexpected death in epilepsy (SUDEP). The exact etiology of SUDEP is unknown, but a combination of respiratory, cardiac, neuronal electrographic dysfunction, and arousal impairment is thought to underlie SUDEP. Serotonin (5-HT) is involved in regulation of breathing, sleep/wake states, arousal, and seizure modulation and has been implicated in the pathophysiology of SUDEP. This review explores the current state of understanding of the relationship between 5-HT, epilepsy, and respiratory and autonomic control processes relevant to SUDEP in epilepsy patients and in animal models.
Details
- Title: Subtitle
- Serotonin and sudden unexpected death in epilepsy
- Creators
- Alexandra N Petrucci - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, United States of AmericaKatelyn G Joyal - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, United States of AmericaBenton S Purnell - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, United States of AmericaGordon F Buchanan - Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, United States of America
- Resource Type
- Journal article
- Publication Details
- Experimental neurology, Vol.325, pp.113145-113145
- DOI
- 10.1016/j.expneurol.2019.113145
- PMID
- 31866464
- NLM abbreviation
- Exp Neurol
- ISSN
- 0014-4886
- eISSN
- 1090-2430
- Publisher
- Elsevier Inc
- Grant note
- name: Post Comprehensive Exam Fellowship from the Graduate College; DOI: 10.13039/100008893, name: University of Iowa; name: Pre-doctoral Fellowship from the American Epilepsy Society/LivaNova; name: NIH/NINDS, award: F31 NS106819; name: NIH/NINDS, award: R01 NS095842; name: Beth L. Tross Epilepsy Professorship
- Language
- English
- Date published
- 03/2020
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984070987802771
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