Serotonin is necessary for place memory in Drosophila

Divya Sitaraman; Melissa Zars; Holly LaFerriere; Yin-Chieh Chen; Alex Sable-Smith; Toshihiro Kitamoto; George E Rottinghaus; Troy Zars

doi:10.1073/pnas.0710168105

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Serotonin is necessary for place memory in Drosophila

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Serotonin is necessary for place memory in Drosophila

Divya Sitaraman, Melissa Zars, Holly LaFerriere, Yin-Chieh Chen, Alex Sable-Smith, Toshihiro Kitamoto, George E Rottinghaus and Troy Zars

Proceedings of the National Academy of Sciences - PNAS, Vol.105(14), pp.5579-5584

04/08/2008

DOI: 10.1073/pnas.0710168105

PMCID: PMC2291120

PMID: 18385379

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Abstract

Biogenic amines, such as serotonin and dopamine, can be important in reinforcing associative learning. This function is evident as changes in memory performance with manipulation of either of these signals. In the insects, evidence begins to argue for a common role of dopamine in negatively reinforced memory. In contrast, the role of the serotonergic system in reinforcing insect associative learning is either unclear or controversial. We investigated the role of both of these signals in operant place learning in Drosophila . By genetically altering serotonin and dopamine levels, manipulating the neurons that make serotonin and dopamine, and pharmacological treatments we provide clear evidence that serotonin, but not dopamine, is necessary for place memory. Thus, serotonin can be critical for memory formation in an insect, and dopamine is not a universal negatively reinforcing signal.

biogenic amines

Biological Sciences

learning

reinforcement

dopamine

white-ABC transporter

Details

Title: Subtitle: Serotonin is necessary for place memory in Drosophila
Creators: Divya Sitaraman - Division of Biological Sciences and
Melissa Zars - Division of Biological Sciences and
Holly LaFerriere - Division of Biological Sciences and
Yin-Chieh Chen - Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, MO 65211; and
Alex Sable-Smith - Division of Biological Sciences and
Toshihiro Kitamoto - Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA 52242
George E Rottinghaus - Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, MO 65211; and
Troy Zars - Division of Biological Sciences and
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.105(14), pp.5579-5584
DOI: 10.1073/pnas.0710168105
PMID: 18385379
PMCID: PMC2291120
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 04/08/2008
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984006355802771

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