Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei

Joanne P Boisvert; Tyler J Boschuetz; Jon M Resch; Christopher R Mueller; Sujean Choi

doi:10.1016/j.neulet.2011.05.011

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Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei

Journal article

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Peer reviewed

Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei

Joanne P Boisvert, Tyler J Boschuetz, Jon M Resch, Christopher R Mueller and Sujean Choi

Neuroscience letters, Vol.498(3), pp.213-217

07/12/2011

DOI: 10.1016/j.neulet.2011.05.011

PMCID: PMC3130612

PMID: 21600959

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https://doi.org/10.1016/j.neulet.2011.05.011View

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Abstract

Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight. To examine possible interactions between 5-HT and neuropeptides in appetite control, fenfluramine (200 nmol/0.5 μl/side) was administered directly into the hypothalamic paraventricular nuclei (PVN) of male rats. Bilateral fenfluramine produced significant hypophagia and increased expression of PVN corticotropin releasing factor (CRF) mRNA and neuropeptide Y (NPY) mRNA in the arcuate nucleus within the first hour after drug administration. Fenfluramine's effects on feeding behavior and mRNA expression were blocked by PVN injections of a 5-HT(1-2) receptor antagonist, metergoline (15 nmol/0.5 μl/side). These data suggest that 5-HT neurons targeting hypothalamic paraventricular CRF neurons may participate in an appetite control circuit for reducing food intake.

Paraventricular Hypothalamic Nucleus - physiology

Serotonin - physiology

Microinjections

Metergoline - administration & dosage

Arcuate Nucleus of Hypothalamus - metabolism

Metergoline - pharmacology

Appetite Regulation - drug effects

Rats

Male

Neuropeptide Y - biosynthesis

Fenfluramine - antagonists & inhibitors

RNA, Messenger - metabolism

Fenfluramine - pharmacology

Rats, Sprague-Dawley

Feeding Behavior - physiology

Corticotropin-Releasing Hormone - biosynthesis

Feeding Behavior - drug effects

Corticotropin-Releasing Hormone - physiology

Paraventricular Hypothalamic Nucleus - drug effects

Animals

Drug Interactions

Paraventricular Hypothalamic Nucleus - metabolism

Fenfluramine - administration & dosage

Appetite Regulation - physiology

Details

Title: Subtitle: Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei
Creators: Joanne P Boisvert - Department of Biomedical Sciences, Marquette University, Schroeder Complex 446, P.O. Box 1881, Milwaukee, WI 53201, United States
Tyler J Boschuetz
Jon M Resch
Christopher R Mueller
Sujean Choi
Resource Type: Journal article
Publication Details: Neuroscience letters, Vol.498(3), pp.213-217
DOI: 10.1016/j.neulet.2011.05.011
PMID: 21600959
PMCID: PMC3130612
NLM abbreviation: Neurosci Lett
ISSN: 0304-3940
eISSN: 1872-7972
Publisher: Ireland
Grant note: DK074734 / NIDDK NIH HHS R01 DK074734-03 / NIDDK NIH HHS R01 DK074734 / NIDDK NIH HHS
Language: English
Date published: 07/12/2011
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984065854902771

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