Journal article
Serotonin signaling by maternal neurons upon stress ensures progeny survival
eLife, Vol.9, e55246
04/23/2020
DOI: 10.7554/eLife.55246
PMID: 32324136
Abstract
Germ cells are vulnerable to stress. Therefore, how organisms protect their future progeny from damage in a fluctuating environment is a fundamental question in biology. We show that in Caenorhabditis elegans, serotonin released by maternal neurons during stress ensures the viability and stress resilience of future offspring. Serotonin acts through a signal transduction pathway conserved between C. elegans and mammalian cells to enable the transcription factor HSF1 to alter chromatin in soon-to-be fertilized germ cells by recruiting the histone chaperone FACT, displacing histones, and initiating protective gene expression. Without serotonin release by maternal neurons, FACT is not recruited by HSF1 in germ cells, transcription occurs but is delayed, and progeny of stressed C. elegans mothers fail to complete development. These studies uncover a novel mechanism by which stress sensing by neurons is coupled to transcription response times of germ cells to protect future offspring.
Details
- Title: Subtitle
- Serotonin signaling by maternal neurons upon stress ensures progeny survival
- Creators
- Srijit Das - Department of Biology, Aging Mind and Brain Initiative, Iowa City, United StatesFelicia K Ooi - Department of Biology, Aging Mind and Brain Initiative, Iowa City, United StatesJohnny Cruz Corchado - Department of Biology, Aging Mind and Brain Initiative, Iowa City, United StatesLeah C Fuller - Department of Biology, Iowa City, United StatesJoshua A Weiner - Department of Biology, Iowa City, United States, Iowa Neuroscience Institute, Iowa City, United StatesVeena Prahlad - Department of Biology, Aging Mind and Brain Initiative, Iowa City, United States, Department of Biology, Iowa City, United States, Iowa Neuroscience Institute, Iowa City, United States
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.9, e55246
- DOI
- 10.7554/eLife.55246
- PMID
- 32324136
- NLM abbreviation
- Elife
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Grant note
- DOI: 10.13039/100008893, name: University of Iowa, award: Aging Mind and Brain Initiative; DOI: 10.13039/100000002, name: National Institutes of Health, award: AG 050653
- Language
- English
- Date published
- 04/23/2020
- Academic Unit
- Liberal Arts and Science Admin; Psychiatry; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984003043602771
Metrics
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