Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder

Raşit Tükel; Elif Alkaş; Hakan Gürvit; Banu Aslantas Ertekin; Erhan Ertekin; Bengi Baran; Şükriye Akça Kalem; Güher Saruhan Direskeneli

doi:10.1080/13854046.2016.1162329

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Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder

Journal article

Peer reviewed

Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder

Raşit Tükel, Elif Alkaş, Hakan Gürvit, Banu Aslantas Ertekin, Erhan Ertekin, Bengi Baran, Şükriye Akça Kalem and Güher Saruhan Direskeneli

Clinical neuropsychologist, Vol.30(4), pp.536-546

05/18/2016

DOI: 10.1080/13854046.2016.1162329

PMID: 26986829

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Abstract

Objective: In the present study, we investigate the association between the 5-HTTLPR polymorphism and executive functions in a sample of patients with obsessive compulsive disorder (OCD). Method: A total of 98 unmedicated patients diagnosed with OCD according to DSM-IV criteria and 80 healthy controls were included in this study. The genotype frequencies of 5-HTTLPR polymorphism were compared in OCD and healthy control groups. The four subgroups of OCD and healthy control participants, determined according to having LaLa genotype (high expressing) or S- and/or Lg alleles (low expressing), were also compared using neuropsychological tests of executive functions. Results: The frequency of SLa genotype of 5-HTTLPR polymorphism was found to be higher in patients with OCD compared with healthy controls. The mean scores of conceptual level responses of the Wisconsin Card Sorting Test (WCST) were significantly lower in the OCD-high-expressing subgroup compared with the low-expressing control group. The mean scores of the number of moves of the Tower of London were found to be significantly higher in the OCD-high-expressing subgroup, compared with the high-expressing subgroup of healthy controls. Conclusion: Our findings suggest that the high-expressing variant may be associated with lower performance on some abstraction and planning measures in OCD patients.

Neuropsychology

OCD

5-HTTLPR

executive functions

genetic polymorphism

Details

Title: Subtitle: Serotonin transporter promoter polymorphism is associated with executive function impairments in patients with obsessive compulsive disorder
Creators: Raşit Tükel - Department of Psychiatry, Istanbul University Istanbul Faculty of Medicine
Elif Alkaş - Istanbul University Istanbul Faculty of Medicine
Hakan Gürvit - Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University Istanbul Faculty of Medicine
Banu Aslantas Ertekin - Department of Psychiatry, Istanbul University Istanbul Faculty of Medicine
Erhan Ertekin - Department of Psychiatry, Istanbul University Istanbul Faculty of Medicine
Bengi Baran - Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University Istanbul Faculty of Medicine
Şükriye Akça Kalem - Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul University Istanbul Faculty of Medicine
Güher Saruhan Direskeneli - Department of Physiology, Istanbul University Istanbul Faculty of Medicine
Resource Type: Journal article
Publication Details: Clinical neuropsychologist, Vol.30(4), pp.536-546
DOI: 10.1080/13854046.2016.1162329
PMID: 26986829
NLM abbreviation: Clin Neuropsychol
ISSN: 1385-4046
eISSN: 1744-4144
Publisher: Routledge
Grant note: BYPS-12-5/131206 / Istanbul University (10.13039/501100002657)
Language: English
Date published: 05/18/2016
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065474702771

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