Journal article
Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal
American journal of clinical pathology, Vol.133(4), pp.623-632
04/2010
DOI: 10.1309/AJCP1UJPX6UURLCH
PMID: 20231616
Abstract
We performed a histologic and immunohistochemical assessment of 53 noninvasive appendiceal epithelial proliferations, appropriating terminology and using markers shown useful in differentiating serrated colorectal polyps. These were classified as hyperplastic polyp (HP), sessile serrated adenoma (SSA), mixed serrated and adenomatous lesion (MSAL), mucinous cystadenoma (MCA), or conventional adenoma (CAD). Immunohistochemical analysis for cytokeratin (CK) 20, Ki-67, MUC6, and beta-catenin was performed. Diagnoses were as follows: HP, 6; SSA, 12; HP vs SSA, 3; MSAL, 16; MCA, 14; and CAD, 2. All HPs showed expanded (beyond surface) CK20 and expanded or normal (base) Ki-67; 1 was MUC6+. Most SSAs and MSALs were CK20-expanded or expanded with random expression in deep crypts (Ex/I) and Ki-67-expanded, Ex/I (expanded with asymmetry), or normal. All SSAs and 8 of 16 MSALs were MUC6+. CADs were CK20-Ex/I, Ki-67-Ex, and MUC6-; 1 showed nuclear beta-catenin expression. Serrated appendiceal lesions can be categorized using colorectal terminology. MUC6 is associated with SSA morphologic features. Similar immunohistochemical patterns in SSA and MSAL suggest a link between these lesions.
Details
- Title: Subtitle
- Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal
- Creators
- Andrew M Bellizzi - Dept of Pathology, Brigham and Women's Hospital, Boston, MA, USAJonathan RockWilliam L MarshWendy L Frankel
- Resource Type
- Journal article
- Publication Details
- American journal of clinical pathology, Vol.133(4), pp.623-632
- Publisher
- England
- DOI
- 10.1309/AJCP1UJPX6UURLCH
- PMID
- 20231616
- ISSN
- 0002-9173
- eISSN
- 1943-7722
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984047628202771
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