Journal article
Sertraline exposure during development may impact post-myocardial infarction survival in adult mice
Physiological reports, Vol.13(22), e70662
11/2025
DOI: 10.14814/phy2.70662
PMCID: PMC12618208
PMID: 41239547
Appears in UI Libraries Support Open Access
Abstract
This study examines sex-specific effects of developmental sertraline exposure on cardiac function and gene expression before and after myocardial infarction (MI) in mice. Female C57BL/6 mice (10 weeks) received intraperitoneal sertraline (5 mg/kg/day, n = 37) or saline (n = 20) before mating, during pregnancy, and postnatally to pups (1.5 mg/kg/day, postnatal Days 0-14). MI in offspring was induced at 10 weeks by left coronary artery ligation. Randomly chosen offspring (sham n = 8 and MI n = 26 per sex) underwent baseline echocardiography and at 10 weeks post-MI if surviving. Serotonin- and estrogen-related gene expression was analyzed. Before MI, sertraline-exposed females had lower heart rate (649.1 ± 102.0 vs. 692.9 ± 38.4 bpm, n = 34), increased end-systolic volume, and reduced ejection fraction (80.7 ± 6.3% vs. 83.9 ± 3.5%; p < 0.05). Exposed males also had lower heart rates (665.9 ± 32.7 vs. 683.3 ± 47.9 bpm, n = 34, p < 0.05). Post-MI, both sexes remodeled similarly (scar size, ischemic-zone fraction); sertraline-exposed males had higher scar-zone collagen (p < 0.05) and a nonsignificant lower survival trend than females. Sertraline altered serotonin-related gene expression (Htr2a, Htr2b, Slc6a4), particularly in male sham mice. Developmental sertraline exposure induces sex-specific cardiac changes, potentially affecting post-MI outcomes, with males showing more structural and survival impairments.
Details
- Title: Subtitle
- Sertraline exposure during development may impact post-myocardial infarction survival in adult mice
- Creators
- Yongjun Lu - University of IowaElizabeth Kenkel - Bristol-Myers SquibbKathy Zimmerman - University of IowaRobert M Weiss - University of IowaRobert D Roghair - University of IowaSarah E Haskell - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Physiological reports, Vol.13(22), e70662
- DOI
- 10.14814/phy2.70662
- PMID
- 41239547
- PMCID
- PMC12618208
- NLM abbreviation
- Physiol Rep
- ISSN
- 2051-817X
- eISSN
- 2051-817X
- Publisher
- Wiley
- Grant note
- K08HL141528 / National Instutites of Health S10OD0038119 / National Instutites of Health S10OD019941 / National Instutites of Health
- Language
- English
- Date published
- 11/2025
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics; Cardiovascular Medicine; Neonatology; Internal Medicine
- Record Identifier
- 9985027465502771
Metrics
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