Journal article
Serum Anti-Heart and Anti-Intercalated Disk Autoantibodies: Novel Autoimmune Markers in Cardiac Sarcoidosis
Journal of clinical medicine, Vol.10(11), p.2476
06/01/2021
DOI: 10.3390/jcm10112476
PMCID: PMC8199734
PMID: 34199661
Abstract
Background: Sarcoidosis is an immune-mediated disease. Cardiac involvement, a granulomatous form of myocarditis, is under-recognized and prognostically relevant. Anti-heart autoantibodies (AHAs) and anti-intercalated disk autoantibodies (AIDAs) are autoimmune markers in nonsarcoidosis myocarditis forms. Objective: The aim was to assess serum AHAs and AIDAs as autoimmune markers in cardiac sarcoidosis. Methods: This is a cross-sectional study on AHA and AIDA frequency in: 29 patients (aged 46 +/- 12, 20 male) with biopsy-proven extracardiac sarcoidosis and biopsy-proven or clinically suspected and confirmed by 18-fluorodeoxyglucose positron emission tomography and/or cardiovascular magnetic resonance (CMR) cardiac involvement; 30 patients (aged 44 +/- 11, 12 male) with biopsy-proven extracardiac sarcoidosis without cardiac involvement (no cardiac symptoms, normal 12-lead electrocardiogram, echocardiography and CMR), and control patients with noninflammatory cardiac disease (NICD) (n = 160), ischemic heart failure (IHF) (n = 141) and normal blood donors (NBDs) (n = 270). Sarcoidosis patients were recruited in two recruiting tertiary centers in the USA and Italy. AHAs and AIDAs were detected by indirect immunofluorescence on the human myocardium and skeletal muscle. Results: AHA and AIDA frequencies were higher in sarcoidosis with cardiac involvement (86%; 62%) than in sarcoidosis without cardiac involvement (0%; 0%), NICD (8%; 4%), IHF (7%; 2%) and NBD (9%; 0%) (p = 0.0001; p = 0.0001, respectively). Sensitivity and specificity for cardiac sarcoidosis were 86% and 92% for positive AHAs and 62% and 98% for positive AIDAs, respectively. AIDAs in cardiac sarcoidosis were associated with a higher number of involved organs (p = 0.04). Conclusions: Serum AHAs and AIDAs provide novel noninvasive diagnostic autoimmune markers for cardiac sarcoidosis.
Details
- Title: Subtitle
- Serum Anti-Heart and Anti-Intercalated Disk Autoantibodies: Novel Autoimmune Markers in Cardiac Sarcoidosis
- Creators
- Alida L. P. Caforio - University of PaduaAnna Baritussio - University of PaduaRenzo Marcolongo - Univ Padua, Dept Med, Hematol & Clin Immunol, I-35100 Padua, ItalyChun-Yan Cheng - Univ Padua, Dept Cardiol Thorac & Vasc Sci & Publ Hlth, Div Cardiol, I-35100 Padua, ItalyElena Pontara - University of PaduaElisa Bison - University of PaduaMaria Grazia Cattini - University of PaduaNicoletta Gallo - University of PaduaMario Plebani - Univ Padua, Dept Lab Med, I-35100 Padua, ItalySabino Iliceto - University of PaduaGianpietro Semenzato - University of PaduaLisa Maier - National Jewish HealthNabeel Hamzeh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical medicine, Vol.10(11), p.2476
- DOI
- 10.3390/jcm10112476
- PMID
- 34199661
- PMCID
- PMC8199734
- NLM abbreviation
- J Clin Med
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Publisher
- Mdpi
- Number of pages
- 11
- Grant note
- Budget Integrato per la Ricerca dei Dipartimenti (BIRD, 2019), Padova University, Padova, Italy
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984360152302771
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