Journal article
Serum Haloperidol Concentrations and Clinical Response in Acute Psychosis
Journal of clinical psychopharmacology, Vol.4(6), pp.305-310
12/1984
DOI: 10.1097/00004714-198412000-00002
PMID: 6511996
Abstract
Steady state serum haloperidol concentrations measured by gas-liquid chromatography and a neuroleptic radioreceptor assay were compared to clinical response in 21 acutely psychotic inpatients. Serum concentrations measured by the two assay methods correlated well with each other, although the neuroleptic radioreceptor assay was much less sensitive. There was also a significant linear relationship between haloperidol dose (mg/ kg/day) and steady state serum concentration. The correlation between haloperidol serum concentrations and clinical response after 2 to 3 weeks was nonlinear and most pronounced in the intermediate range (15 to 40 ng/ml). Further studies will be needed to establish with certainty the existence and exact limits of a therapeutic window.
Details
- Title: Subtitle
- Serum Haloperidol Concentrations and Clinical Response in Acute Psychosis
- Creators
- DEL D MILLERLINDA A HERSHEYJ. PATRICK DUFFYDARRELL R ABERNETHYDAVID J GREENBLATT
- Resource Type
- Journal article
- Publication Details
- Journal of clinical psychopharmacology, Vol.4(6), pp.305-310
- DOI
- 10.1097/00004714-198412000-00002
- PMID
- 6511996
- ISSN
- 0271-0749
- eISSN
- 1533-712X
- Language
- English
- Date published
- 12/1984
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003440402771
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