Journal article
Serum Immunoglobulin G Response to Human Papillomavirus Type 16 Virus-Like Particles in Human Immunodeficiency Virus (HIV)–Positive and Risk-Matched HIV-Negative Women
The Journal of infectious diseases, Vol.187(2), pp.194-205
01/15/2003
DOI: 10.1086/346052
PMID: 12552444
Abstract
Baseline serum samples from 2815 human immunodeficiency virus (HIV)–positive and 963 HIV-negative women enrolled in 2 cohort studies were tested for immunoglobulin G antibodies to human papillomavirus type 16 (HPV-16) capsids. HPV-16 seropositivity was associated with lifetime number of sex partners (P<.001) among both HIV-positive and HIV-negative women. Approximately 50%–60% of HPV-16 DNA–positive women were HPV-16 positive. HPV-16 seropositivity was associated with HIV infection; however, after adjustment for baseline cervical HPV infection and disease, the association disappeared. Thus, the high seroprevalence of HPV-16 among HIV-positive women may be explained by a high prevalence of HPV of all types. Approximately 50% of HIV-positive women had serological evidence of prior HPV-16 infection, but only ∼5% had an HPV-16 cervical infection at baseline. Despite the higher prevalence of HPV infection in this group, most HIV-positive women are able to control HPV-16 replication at the cervix, and reactivation, if it occurs, is not very common
Details
- Title: Subtitle
- Serum Immunoglobulin G Response to Human Papillomavirus Type 16 Virus-Like Particles in Human Immunodeficiency Virus (HIV)–Positive and Risk-Matched HIV-Negative Women
- Creators
- Raphael P. Viscidi - Johns Hopkins UniversityLinda Ahdieh-Grant - School of Public Health, Baltimore, andBarbara Clayman - Johns Hopkins UniversityKelly Fox - School of Public Health, Baltimore, andLeslie S. Massad - John H. Stroger, Jr. Hospital of Cook CountySusan Cu-Uvin - Miriam HospitalKeerti V. Shah - School of Public Health, Baltimore, andKathryn M. Anastos - Montefiore Medical CenterKathleen E. Squires - University of Southern CaliforniaAnn Duerr - Centers for Disease Control and PreventionDenise J. Jamieson - Centers for Disease Control and PreventionRobert D. Burk - Albert Einstein College of MedicineRobert S. Klein - Montefiore Medical CenterHoward Minkoff - Maimonides Medical CenterJoel Palefsky - University of California, San FranciscoHoward Strickler - Albert Einstein College of MedicinePaula Schuman - Wayne State UniversityEva Piessens - Georgetown University Medical CenterPaolo Miotti - National Institute of Allergy and Infectious Diseases
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.187(2), pp.194-205
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/346052
- PMID
- 12552444
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 01/15/2003
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446539102771
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