Serum Levels of Homocysteine, Vitamin B12, and Folic Acid in Patients with Alzheimer's Disease

Fariba Karimi; Afshin Haghighi; Payman Petramfar

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Serum Levels of Homocysteine, Vitamin B12, and Folic Acid in Patients with Alzheimer's Disease

Journal article

Open access

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Serum Levels of Homocysteine, Vitamin B12, and Folic Acid in Patients with Alzheimer's Disease

Fariba Karimi, Afshin Haghighi and Payman Petramfar

Iranian journal of medical sciences, Vol.34(3), pp.181-185

09/01/2009

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Abstract

Background: Alzheimer's disease is the most common form of dementia in the elderly. Serum levels of homocysteine have been related to increased cortical and hippocampal atrophy. We aimed to determine the serum levels of homocysteine, folate, and vitamin B-12 in patients with Alzheimer's disease. Methods: Blood levels of homocysteine and its biological determinants, folate, and vitamin B12 were measured in 51 patients who were diagnosed as having Alzheimer's disease according to DSM-IV criteria and compared with the serum levels obtained from 49 control individuals. Results: The mean serum homocysteine concentration was significantly higher in patients with Alzheimer's disease than the controls (20.4 +/- 16.5 mu mol/L v 14.5 +/- 5 mu mol/L; P=0.02). There were no statistically significant differences between the mean serum levels of vitamin B-12 (P=0.6) and folate (P=0.3) in the patients and the controls. There was no correlation between age and serum homocysteine concentration in both groups (P=0.8). Conclusion: Serum homocysteine concentration was significantly higher in the patients with Alzheimer's disease. This biomarker might be considered as a predictor of cognitive performance.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Details

Title: Subtitle: Serum Levels of Homocysteine, Vitamin B12, and Folic Acid in Patients with Alzheimer's Disease
Creators: Fariba Karimi - Shiraz University
Afshin Haghighi - Shiraz University
Payman Petramfar - Shiraz University
Resource Type: Journal article
Publication Details: Iranian journal of medical sciences, Vol.34(3), pp.181-185
ISSN: 0253-0716
eISSN: 1735-3688
Publisher: Shiraz Univ Medical Sciences
Number of pages: 5
Grant note: 86-3442 / Vice Chancellor for Research, Shiraz University of Medical Sciences
Language: English
Date published: 09/01/2009
Academic Unit: Neurology
Record Identifier: 9985013728102771

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