Serum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. MESA (Multi-Ethnic Study of Atherosclerosis)

Hilary F Armstrong; Anna J Podolanczuk; R Graham Barr; Elizabeth C Oelsner; Steven M Kawut; Eric A Hoffman; Russell Tracy; Naftali Kaminski; Robyn L McClelland; David J Lederer

doi:10.1164/rccm.201701-0254OC

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Serum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. MESA (Multi-Ethnic Study of Atherosclerosis)

Journal article

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Peer reviewed

Serum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. MESA (Multi-Ethnic Study of Atherosclerosis)

Hilary F Armstrong, Anna J Podolanczuk, R Graham Barr, Elizabeth C Oelsner, Steven M Kawut, Eric A Hoffman, Russell Tracy, Naftali Kaminski, Robyn L McClelland and David J Lederer

American journal of respiratory and critical care medicine, Vol.196(10), pp.1311-1317

11/15/2017

DOI: 10.1164/rccm.201701-0254OC

PMCID: PMC5694831

PMID: 28570100

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Abstract

Matrix metalloproteinase-7 (MMP-7) has been implicated in interstitial lung disease pathobiology and proposed as a diagnostic and prognostic biomarker of idiopathic pulmonary fibrosis. To test associations between serum MMP-7 and lung function, respiratory symptoms, interstitial lung abnormalities (ILA), and all-cause mortality in community-dwelling adults sampled without regard to respiratory symptoms or disease. We measured serum MMP-7 in 1,227 participants in MESA (Multi-Ethnic Study of Atherosclerosis) at baseline. The 5-year outcome data were available for spirometry (n = 697), cough (n = 722), and dyspnea (n = 1,050). The 10-year outcome data were available for ILA (n = 561) and mortality (n = 1,227). We used linear, logistic, and Cox regression to control for potential confounders. The mean (±SD) serum MMP-7 level was 4.3 (±2.5) ng/ml (range, 1.2-24.1 ng/ml). In adjusted models, each natural log unit increment in serum MMP-7 was associated with a 3.7% absolute decrement in FVC% (95% confidence interval [CI] = 0.9-6.6%), a 1.6-fold increased odds of exertional dyspnea (95% CI = 1.3-1.9), a 1.5-fold increased odds of ILAs (95% CI = 1.1-2.1), and a 2.2-fold increased all-cause mortality rate (95% CI = 1.9-2.5). The associations with ILA and mortality tended to be stronger among never-smokers (P values for interaction 0.06 and 0.01, respectively). Serum MMP-7 levels may be a quantitative biomarker of subclinical extracellular matrix remodeling in the lungs of community-dwelling adults, which may facilitate investigation of subclinical interstitial lung disease.

Ethnic Groups - statistics & numerical data

Independent Living - statistics & numerical data

Matrix Metalloproteinase 7 - blood

Humans

Middle Aged

Male

Asymptomatic Diseases - mortality

Lung Diseases, Interstitial - mortality

Aged, 80 and over

Adult

Female

Aged

Lung Diseases, Interstitial - physiopathology

Details

Title: Subtitle: Serum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. MESA (Multi-Ethnic Study of Atherosclerosis)
Creators: Hilary F Armstrong - 1 Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York
Anna J Podolanczuk - 2 Department of Medicine, Columbia University Medical Center, New York, New York
R Graham Barr - 2 Department of Medicine, Columbia University Medical Center, New York, New York
Elizabeth C Oelsner - 2 Department of Medicine, Columbia University Medical Center, New York, New York
Steven M Kawut - 4 Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
Eric A Hoffman - 5 Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, Iowa
Russell Tracy - 6 Department of Pathology, University of Vermont, Burlington, Vermont
Naftali Kaminski - 7 Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut; and
Robyn L McClelland - 8 Department of Biostatistics, University of Washington, Seattle, Washington
David J Lederer - 2 Department of Medicine, Columbia University Medical Center, New York, New York
Resource Type: Journal article
Publication Details: American journal of respiratory and critical care medicine, Vol.196(10), pp.1311-1317
DOI: 10.1164/rccm.201701-0254OC
PMID: 28570100
PMCID: PMC5694831
NLM abbreviation: Am J Respir Crit Care Med
ISSN: 1073-449X
eISSN: 1535-4970
Publisher: United States
Grant note: N01HC95169 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS T32 HL105323 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS RC1 HL100543 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS R01 HL103676 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS K23 HL130627 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL093081 / NHLBI NIH HHS HHSN268201500003C / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS R01 HL071205 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS N01HC95168 / NHLBI NIH HHS K24 HL131937 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS
Language: English
Date published: 11/15/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051770402771

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