Journal article
Serum Uric Acid Level and Endothelial Dysfunction in Patients with Nondiabetic Chronic Kidney Disease
American journal of nephrology, Vol.33(4), pp.298-304
04/2011
DOI: 10.1159/000324847
PMCID: PMC3064939
PMID: 21389694
Abstract
Background: An elevated serum uric acid level is strongly associated with endothelial dysfunction and inflammation, both of which are common in chronic kidney disease (CKD). We hypothesized that endothelial dysfunction in subjects with CKD would correlate with uric acid levels. Materials and Methods: We evaluated the association between serum uric acid level and ultrasonographic flow-mediated dilatation (FMD) in 263 of 486 patients with recently diagnosed CKD (stage 3–5) (48% male, age 52 ± 12 years). To minimize confounding, 233 patients were excluded because they were diabetic, had established cardiovascular complications or were taking drugs (renin-angiotensin system blockers, statins) interfering with vascular function. Results: Serum uric acid level was significantly increased in all stages of CKD and strongly correlated with estimated glomerular filtration rate (eGFR-MDRD); FMD was inversely associated with serum uric acid (r = –0.49, p < 0.001). The association of serum uric acid with FMD remained after adjustment for age, gender, smoking, LDL cholesterol, eGFR, high-sensitivity C-reactive protein, systolic blood pressure, proteinuria, and homeostatic model assessment index (β = –0.27, p < 0.001). Conclusion: Increased serum uric acid is an independent predictor of endothelial dysfunction in subjects with CKD.
Details
- Title: Subtitle
- Serum Uric Acid Level and Endothelial Dysfunction in Patients with Nondiabetic Chronic Kidney Disease
- Creators
- Mehmet Kanbay - Division of Nephrology, Gulhane School of Medicine, Ankara, TurkeyMahmut Ilker Yilmaz - Division of Nephrology, Gulhane School of Medicine, Ankara, TurkeyAlper Sonmez - Division of Endocrinology, Department of Medicine, Gulhane School of Medicine, Ankara, TurkeyFaruk Turgut - Division of Nephrology, Gulhane School of Medicine, Ankara, TurkeyMutlu Saglam - Department of Radiology, Gulhane School of Medicine, Ankara, TurkeyErdinc Cakir - Department of Biochemistry, Gulhane School of Medicine, Ankara, TurkeyMujdat Yenicesu - Division of Nephrology, Gulhane School of Medicine, Ankara, TurkeyAdrian Covic - Nephrology Clinic, Dialysis and Renal Transplant Center, ‘C.I. Parhon’ University Hospital, ‘Gr. T. Popa’ University of Medicine and Pharmacy, Iasi, RomaniaDiana Jalal - Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colo., USARichard J Johnson - Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colo., USA
- Resource Type
- Journal article
- Publication Details
- American journal of nephrology, Vol.33(4), pp.298-304
- Publisher
- S. Karger AG
- DOI
- 10.1159/000324847
- PMID
- 21389694
- PMCID
- PMC3064939
- ISSN
- 0250-8095
- eISSN
- 1421-9670
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094635202771
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