Journal article
Serum Uric Acid and Hypertension in Adults: A Paradoxical Relationship in Type 1 Diabetes
The journal of clinical hypertension (Greenwich, Conn.), Vol.16(4), pp.283-288
04/01/2014
DOI: 10.1111/jch.12305
PMCID: PMC3989383
PMID: 24667019
Abstract
Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults. Little is known about the relationship between serum uric acid and blood pressure in type 1 diabetes and whether it differs from the positive relationship found in nondiabetic adults. The authors assessed the cross-sectional and longitudinal relationships over 6 years between serum uric acid and blood pressure in adults with (35 +/- 9years [n=393]) and without (38 +/- 9years [n=685]) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. In nondiabetic adults, serum uric acid was associated with systolic blood pressure in multivariable models adjusted for cardiovascular risk factors. In adults with type 1 diabetes, a negative association was observed between serum uric acid and systolic blood pressure after multivariable adjustments. A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes.
Details
- Title: Subtitle
- Serum Uric Acid and Hypertension in Adults: A Paradoxical Relationship in Type 1 Diabetes
- Creators
- Petter Bjornstad - University of Colorado Anschutz Medical CampusR. Paul Wadwa - University of Colorado Anschutz Medical CampusJeffrey C. Sirota - University of Colorado Anschutz Medical CampusJanet K. Snell-Bergeon - University of Colorado Anschutz Medical CampusKimberly McFann - University of Colorado Anschutz Medical CampusMarian Rewers - University of Colorado Anschutz Medical CampusChristopher J. Rivard - University of Colorado Anschutz Medical CampusDiana Jalal - University of Colorado Anschutz Medical CampusMichel B. Chonchol - University of Colorado Anschutz Medical CampusRichard J. Johnson - University of Colorado Anschutz Medical CampusDavid M. Maahs - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- The journal of clinical hypertension (Greenwich, Conn.), Vol.16(4), pp.283-288
- DOI
- 10.1111/jch.12305
- PMID
- 24667019
- PMCID
- PMC3989383
- NLM abbreviation
- J Clin Hypertens (Greenwich)
- ISSN
- 1524-6175
- eISSN
- 1751-7176
- Publisher
- Wiley
- Number of pages
- 6
- Grant note
- 1-10-JF-50 / American Diabetes Association Junior Faculty Award; American Diabetes Association R01HL079611 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01 HL61753; HL79611 / NHLBI grant JDRF cardio-renal grant Colorado Heart Imaging Center in Denver, CO M01RR000051 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1TR001082 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) P30 DK57516 / DERC Clinical Investigation Core NIH-M01-RR00051 / Barbara Davis Center for Childhood Diabetes P30DK048520 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359953602771
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