Journal article
Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study
Scientific reports, Vol.9(Aug (E-published)), pp.11367-9
08/06/2019
DOI: 10.1038/s41598-019-47761-w
PMCID: PMC6684630
PMID: 31388056
Abstract
Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-smokers from the SPIROMICS cohort. We measured 27 serum metabolites, mostly amino acids, by
1
H-nuclear magnetic resonance spectroscopy in 157 white ever-smokers with and without COPD. We tested the association between log-transformed metabolite concentrations and one-year incidence of respiratory exacerbations after adjusting for age, sex, current smoking, body mass index, diabetes, inhaled or oral corticosteroid use, study site and clinical predictors of exacerbations, including FEV
1
% predicted and history of exacerbations. The mean age of participants was 53.7 years and 58% had COPD. Lower concentrations of serum amino acids were independently associated with 1-year incidence of respiratory exacerbations, including tryptophan (β = −4.1, 95% CI [−7.0; −1.1], p = 0.007) and the branched-chain amino acids (leucine: β = −6.0, 95% CI [−9.5; −2.4], p = 0.001; isoleucine: β = −5.2, 95% CI [−8.6; −1.8], p = 0.003; valine: β = −4.1, 95% CI [−6.9; −1.4], p = 0.003). Tryptophan concentration was inversely associated with the blood neutrophil-to-lymphocyte ratio (p = 0.03) and the BODE index (p = 0.03). Reduced serum amino acid concentrations in ever-smokers with and without COPD are associated with an increased incidence of respiratory exacerbations.
Details
- Title: Subtitle
- Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study
- Creators
- Wassim W. Labaki - University of MichiganTian Gu - University of MichiganSusan Murray - University of MichiganJeffrey L. Curtis - University of MichiganLarisa Yeomans - University of MichiganRussell P. Bowler - National Jewish HealthR. Graham Barr - Columbia UniversityAlejandro P. Comellas - University of IowaNadia N. Hansel - Johns Hopkins UniversityChristopher B. Cooper - University of California, Los AngelesIgor Barjaktarevic - University of California, Los AngelesRichard E. Kanner - University of UtahRobert Paine - University of UtahMerry-Lynn N. McDonald - University of Alabama at BirminghamJerry A. Krishnan - University of Illinois ChicagoStephen P. Peters - Wake Forest UniversityPrescott G. Woodruff - University of California, San FranciscoWanda K. O’Neal - Chapel Hill, NC USAWenqi Diao - Peking University Third HospitalBei He - Peking University Third HospitalFernando J. Martinez - Cornell UniversityTheodore J. Standiford - University of MichiganKathleen A. Stringer - University of MichiganMeiLan K. Han - University of Michigan
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.9(Aug (E-published)), pp.11367-9
- DOI
- 10.1038/s41598-019-47761-w
- PMID
- 31388056
- PMCID
- PMC6684630
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- Nature Publishing Group UK
- Grant note
- ; I01 CX000911; R01GM111400; R01HL122438; K24HL138188 / ; T32HL007749 / ;
- Language
- English
- Date published
- 08/06/2019
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984360158402771
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