Journal article
Serum and Macular Carotenoids in Relation to Retinal Vessel Caliber Fifteen Years Later, in the Second Carotenoids in Age-Related Eye Disease Study
Investigative ophthalmology & visual science, Vol.62(9), 20
07/01/2021
DOI: 10.1167/iovs.62.9.20
PMCID: PMC8288049
PMID: 34254974
Abstract
PURPOSE. We investigated whether dietary carotenoids lutein and zeaxanthin (L/Z) in the serum and macula were associated with central retinal arteriole and venule calibers in a follow-up ancillary study among older women in the Women's Health Initiative.
METHODS. Among 390 women who participated in Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2) (2016-2019), we investigated associations between serum L/Z at Women's Health Initiative baseline (1994-1998), and macular pigment optical density (MPOD) at CAREDS baseline (2001-2004), with central retinal vessel caliber in CAREDS2. MPOD was measured using heterochromatic flicker photometry (0.5 degrees from the foveal center) in CAREDS baseline and CAREDS2. Vessel calibers were measured from fundus photographs (CAREDS2). We also explored associations in women with stable MPOD (+/- 0.10 optical density units) over 15 years (n = 106), given the long-term increases in MPOD related to diet patterns and supplement use. Associations were investigated using linear modeling.
RESULTS. In the full sample (n = 390), higher serum L/Z (tertile 3 vs. 1) was positively associated with arteriole caliber (mean +/- SE, 145.0 +/- 1.4 mu m vs. 140.8 +/- 1.4 mu m; P = 0.05) and venule caliber (214.6 +/- 2.2 mu m vs. 207.5 +/- 2.2 mu m; P = 0.03). MPOD was also associated with wider vessel calibers (tertile 3 vs. 1), but the trend was only statistically significant for venules (144.4 +/- 1.4 mu m vs. 141.1 +/- 1.4 mu m [P = 0.121 and 213.3 +/- 2.1 mu m vs. 206.0 +/- 2.1 mu m [P = 0.02], respectively.) Most associations were strengthened in women with stable MPOD over 15 years, including between MPOD and arteriole caliber (149.8 +/- 2.6 mu m vs.135.8 +/- 3.0 mu m; P = 0.001).
CONCLUSIONS. Higher L/Z status in serum and retina was associated with larger central retinal vessel calibers. Prospective studies and clinical trials are needed to elucidate whether L/Z supplementation prevents vision loss through increasing blood flow.
Details
- Title: Subtitle
- Serum and Macular Carotenoids in Relation to Retinal Vessel Caliber Fifteen Years Later, in the Second Carotenoids in Age-Related Eye Disease Study
- Creators
- Thomas Lawler - University of Wisconsin–MadisonJackson Korger - University of Wisconsin–MadisonYao Liu - University of Wisconsin–MadisonZhe Liu - University of Wisconsin–MadisonJeong W. Pak - University of Wisconsin–MadisonNancy Barrett - University of Wisconsin–MadisonBarbara Blodi - University of Wisconsin–MadisonAmitha Domalpally - University of Wisconsin–MadisonElizabeth Johnson - Tufts UniversityRobert Wallace - University of IowaJulie A. Mares - University of Wisconsin–MadisonCarotenoids in Age-Related Eye Disease Study Investigators
- Contributors
- Jennifer Robinson (Contributor) - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.62(9), 20
- DOI
- 10.1167/iovs.62.9.20
- PMID
- 34254974
- PMCID
- PMC8288049
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Publisher
- Assoc Research Vision Ophthalmology Inc
- Number of pages
- 10
- Grant note
- Dan and Ellie Albert Medical Student Scholarship Fund T32 DK007665 / Molecular and Applied Nutrition Training Program (MANTP) NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1 TR002373 / NIH/NCATS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UW ICTR Basic and Clinical Translational Research Pilot Award P30 EY016665 / Visual Sciences - National Eye Institute Vision Research Core grant Shapiro Scholarship to Jackson Korger from the University of Wisconsin (UW) EY013018; EY016886; EY025292; EY025292-01S1 / National Eye Institute - Office of Dietary Supplements - UW Madison Department of Ophthalmology and Visual Sciences HHSN268201600018C; HHSN268201600001C; HHSN268201600002C; HHSN268201 600003C; HHSN268201600004C / National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) McPherson Eye Research Institute Lions Eye Bank of Wisconsin Gift of Sight Discovery Fund Research to Prevent Blindness, Inc., to the UW Madison Department of Ophthalmology; Research to Prevent Blindness (RPB) Wisconsin Academy for Rural Medicine (WARM) American Glaucoma Society Mentoring for Advancement of Physician-Scientists (MAPS) Award School of Medicine and Public Health, Dean's Office, Department of Ophthalmology and Visual Sciences
- Language
- English
- Date published
- 07/01/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363573702771
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