Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content

Timothy M Bahr; Sylvia Tan; Emily Smith; Sandra S Beauman; Kurt R Schibler; Cathy A Grisby; Jean R Lowe; Edward F Bell; Abbot R Laptook; Seetha Shankaran; David P Carlton; Carrie Rau; Mariana C Baserga; John Flibotte; Kristin Zaterka-Baxter; Michele C Walsh; Abhik Das; Robert D Christensen; Robin K Ohls

doi:10.1038/s41372-023-01751-z

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Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content

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Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content

Timothy M Bahr, Sylvia Tan, Emily Smith, Sandra S Beauman, Kurt R Schibler, Cathy A Grisby, Jean R Lowe, Edward F Bell, Abbot R Laptook, Seetha Shankaran, …

Journal of perinatology, Vol.43(11), pp.1368-1373

11/2023

DOI: 10.1038/s41372-023-01751-z

PMCID: PMC10825191

PMID: 37596391

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10825191/pdf/nihms-1957076.pdfView

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Abstract

Objectives: To compare serum ferritin and RET-He values among extremely low gestational age neonates ELGANs with other markers of iron-deficient erythropoiesis. Study design: This is a secondary analysis of the NICHD Darbepoetin Trial. Study data from placebo recipients who had a serum ferritin, a RET-He, and a mean corpuscular volume (MCV) measurement within a 24-hour period were analyzed for correlation. Results: Mixed linear regression models showed no association between ferritin and RET-He at both early (β = 0.0016, p = 0.40) and late (β = -0.0001, p = 0.96) time points. Positive associations were observed between RET-He and MCV at baseline, early, and late time points (p < 0.01, =0.01, <0.001, respectively), while ferritin was not associated with MCV at any time point. Conclusions: Our study shows that RET-He is better correlated with MCV as a marker of iron-limited erythropoiesis than ferritin. The results suggest that ferritin is limited as a marker of iron sufficiency in premature infants. Study identification: FDA IND Number 100138; ClinicalTrials.gov number NCT03169881; NRN ID number NICHD-NRN-0058 (Darbe).

Details

Title: Subtitle: Serum ferritin values in neonates <29 weeks' gestation are highly variable and do not correlate with reticulocyte hemoglobin content
Creators: Timothy M Bahr - Intermountain Healthcare
Sylvia Tan - RTI International
Emily Smith - RTI International
Sandra S Beauman - University of New Mexico
Kurt R Schibler - Cincinnati Children's Hospital Medical Center
Cathy A Grisby - Cincinnati Children's Hospital Medical Center
Jean R Lowe - University of New Mexico
Edward F Bell - University of Iowa
Abbot R Laptook - Brown University
Seetha Shankaran - Wayne State University
David P Carlton - Emory University
Carrie Rau - University of Utah
Mariana C Baserga - University of Utah
John Flibotte - University of Pennsylvania
Kristin Zaterka-Baxter - RTI International
Michele C Walsh - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Abhik Das - RTI International
Robert D Christensen - Intermountain Healthcare
Robin K Ohls - University of Utah
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.43(11), pp.1368-1373
DOI: 10.1038/s41372-023-01751-z
PMID: 37596391
PMCID: PMC10825191
NLM abbreviation: J Perinatol
eISSN: 1476-5543
Language: English
Electronic publication date: 08/18/2023
Date published: 11/2023
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984458060302771

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