Journal article
Serum hepcidin levels in chronic liver disease: a systematic review and meta-analysis
Clinical chemistry and laboratory medicine, Vol.62(3), pp.373-384
02/26/2024
DOI: 10.1515/cclm-2023-0540
Abstract
Abstract Objectives Dysregulation of hepcidin-iron axis is presumed to account for abnormal iron status in patients with chronic liver disease (CLD). Our aim is to determine the effect of specific etiologies of CLD and of cirrhosis on serum hepcidin levels. Methods Pubmed, Embase, Web of Science were searched for studies comparing serum hepcidin levels in patients with CLD to that in controls using enzyme-linked immunosorbent assay. The study was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Guidelines. Statistical analysis was carried out with STATA using random effects model to calculate the mean difference (MD) between two groups. Results Hepcidin levels were significantly lower in subjects with hepatitis C virus (16 studies) [MD −1.6 (95 % CI: −2.66 to −0.54), p<0.01] and alcoholic liver disease (3 studies) [MD −0.84 (95 % CI: −1.6 to −0.07), p=0.03] than controls. Serum hepcidin was significantly higher in subjects with non-alcoholic fatty liver disease (12 studies) [MD 0.62 (95 % CI: 0.21 to 1.03), p<0.01], but did not differ in subjects with hepatitis B and controls (eight studies) [MD −0.65 (95 % CI: −1.47 to 0.16), p=0.12]. Hepcidin levels were significantly lower in patients with cirrhosis of any etiology (four studies) [MD −1.02 (CI: −1.59 to −0.45), p<0.01] vs. controls (CI: confidence interval). Conclusions Serum hepcidin levels are altered in common forms of CLD albeit not in a consistent direction. Additional study is needed to determine how changes in hepcidin levels are related to dysregulation of iron metabolism in CLD.
Details
- Title: Subtitle
- Serum hepcidin levels in chronic liver disease: a systematic review and meta-analysis
- Creators
- Ruchi Sharma - University of IowaWeidan Zhao - Department of Internal Medicine , University of Iowa Carver College of Medicine , Iowa City , IA , USA, Department of Gastroenterology-Hepatology , SUNY Downstate , Brooklyn , NY , USAYousaf Zafar - University of Mississippi Medical CenterArvind R. Murali - University of IowaKyle E. Brown - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical chemistry and laboratory medicine, Vol.62(3), pp.373-384
- DOI
- 10.1515/cclm-2023-0540
- ISSN
- 1434-6621
- eISSN
- 1437-4331
- Language
- English
- Electronic publication date
- 08/07/2023
- Date published
- 02/26/2024
- Academic Unit
- Gastroenterology and Hepatology; Radiation Oncology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984454060102771
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