Serum lipid changes following the onset of depressive symptoms in postmenopausal women

Jane E Persons; Jennifer G Robinson; Martha E Payne; Jess G Fiedorowicz

doi:10.1016/j.psychres.2016.12.006

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Serum lipid changes following the onset of depressive symptoms in postmenopausal women

Journal article

Peer reviewed

Serum lipid changes following the onset of depressive symptoms in postmenopausal women

Jane E Persons, Jennifer G Robinson, Martha E Payne and Jess G Fiedorowicz

Psychiatry research, Vol.247, pp.282-287

01/2017

DOI: 10.1016/j.psychres.2016.12.006

PMCID: PMC6004601

PMID: 27940323

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Abstract

A cross-sectional association between depression and serum low-density lipoprotein cholesterol (LDL-c) has been noted in psychiatric literature, raising the question of temporality: does low LDL-c predict depression, does depression lead to changes in LDL-c levels, or is this relationship bidirectional? In a previous longitudinal analysis of postmenopausal women ages 50-79 who participated in the Women's Health Initiative (WHI), we detected an association between low LDL-c and the subsequent onset of depressive symptoms (HR=1.25, 95% CI 1.05-1.49, p=0.01). This current study uses the WHI cohort to explore the question of temporality in the opposite direction, examining the influence of depressive symptoms on subsequent changes in LDL-c levels. This study provides no evidence to suggest an association between depression and subsequent changes in LDL-c level (-2.78mg/dL, 95% CI=-7.49 to 1.92, p=0.25), nor was any association detected for total cholesterol, HDL, or triglyceride changes over time. Further, this study demonstrates that the relationship between depression and serum LDL changes is not mediated by changes in weight, exercise, or energy intake.

Postmenopause - blood

Cross-Sectional Studies

Time Factors

Cholesterol - blood

Humans

Middle Aged

Triglycerides - blood

Cholesterol, HDL - blood

Cholesterol, LDL - blood

Female

Postmenopause - psychology

Depression - blood

Details

Title: Subtitle: Serum lipid changes following the onset of depressive symptoms in postmenopausal women
Creators: Jane E Persons - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USA. Electronic address: jane-persons@uiowa.edu
Jennifer G Robinson - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
Martha E Payne - Office of Research Development, Duke University Medical Center, Durham, NC, USA
Jess G Fiedorowicz - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IA, USA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; François M. Abboud Cardiovascular Research Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Psychiatry research, Vol.247, pp.282-287
DOI: 10.1016/j.psychres.2016.12.006
PMID: 27940323
PMCID: PMC6004601
NLM abbreviation: Psychiatry Res
ISSN: 0165-1781
eISSN: 1872-7123
Publisher: Ireland
Grant note: P01 HL014388 / NHLBI NIH HHS K12 HD043446 / NICHD NIH HHS U54 TR001356 / NCATS NIH HHS
Language: English
Date published: 01/2017
Academic Unit: Psychiatry; Epidemiology; Iowa Neuroscience Institute; Internal Medicine
Record Identifier: 9983995057302771

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