Journal article
Serum serotonin levels in patients with epileptic seizures
Epilepsia (Copenhagen), Vol.59(6), pp.e91-e97
06/2018
DOI: 10.1111/epi.14198
PMCID: PMC6141199
PMID: 29771456
Abstract
Profound cardiovascular and/or respiratory dysfunction is part of the terminal cascade in sudden unexpected death in epilepsy (SUDEP). Central control of ventilation is mediated by brainstem rhythm generators, which are influenced by a variety of inputs, many of which use the modulatory neurotransmitter serotonin to mediate important inputs for breathing. The aim of this study was to investigate epileptic seizure-induced changes in serum serotonin levels and whether there are potential implications for SUDEP. Forty-one epileptic patients were pooled into 2 groups based on seizure type as (1) generalized tonic-clonic seizures (GTCS) of genetic generalized epilepsy and focal to bilateral tonic-clonic seizures (FBTCS; n = 19) and (2) focal seizures (n = 26) based on clinical signs using surface video-electroencephalography. Postictal serotonin levels were statistically significantly higher after GTCS and FBTCS compared to interictal levels (P = .002) but not focal seizures (P = .941). The change in serotonin (postictal-interictal) was inversely associated with a shorter duration of tonic phase of generalized seizures. The interictal serotonin level was inversely associated with a shorter period of postictal generalized electroencephalographic suppression. These data suggest that peripheral serum serotonin levels may play a role in seizure features and earlier postseizure recovery; these findings merit further study.
Details
- Title: Subtitle
- Serum serotonin levels in patients with epileptic seizures
- Creators
- Arun Murugesan - Department of Neurology, Case Western Reserve University, Cleveland, OH, USAM R Sandhya Rani - Center for SUDEP Research, National Institute for Neurological Disorders and Stroke, Cleveland, OH, USAJohnson Hampson - Neurological Institute, University Hospitals, Cleveland, OH, USABilal Zonjy - Center for SUDEP Research, National Institute for Neurological Disorders and Stroke, Cleveland, OH, USANuria Lacuey - Neurological Institute, University Hospitals, Cleveland, OH, USACarl L Faingold - Department of Pharmacology and Neurology, Southern Illinois University School of Medicine, Springfield, IL, USADaniel Friedman - Department of Neurology, New York University School of Medicine, New York, NY, USAOrrin Devinsky - Department of Neurology, New York University School of Medicine, New York, NY, USARup K Sainju - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USAStephan Schuele - Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USABeate Diehl - Institute of Neurology, University College London, London, UKMaromi Nei - Department of Neurology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USARonald M Harper - Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USALisa M Bateman - Department of Neurology, Columbia University Medical Center, New York, NY, USAGeorge Richerson - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USASamden D Lhatoo - Neurological Institute, University Hospitals, Cleveland, OH, USA
- Resource Type
- Journal article
- Publication Details
- Epilepsia (Copenhagen), Vol.59(6), pp.e91-e97
- DOI
- 10.1111/epi.14198
- PMID
- 29771456
- PMCID
- PMC6141199
- NLM abbreviation
- Epilepsia
- ISSN
- 0013-9580
- eISSN
- 1528-1167
- Publisher
- United States
- Grant note
- U01 NS090415 / NINDS NIH HHS U01 NS090405 / NINDS NIH HHS U01 NS090407 / NINDS NIH HHS U01 NS090414 / NINDS NIH HHS
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020754302771
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