Journal article
Serum urate levels and the risk of hip fractures: data from the Cardiovascular Health Study
Metabolism, clinical and experimental, Vol.64(3), pp.438-446
03/2015
DOI: 10.1016/j.metabol.2014.11.006
PMCID: PMC4312534
PMID: 25491429
Abstract
Uric acid inhibits vitamin D activation experimentally and higher serum urate levels are associated with higher parathyroid hormone levels in humans suggesting a link between uric acid and bone health. We hypothesized that hyperuricemia may increase the risk of fractures in older adults.
1963 men and 2729 women ≥65years of age who participated in the Cardiovascular Health Study and had baseline serum urate levels were included in the study. The primary outcome was incident hip fracture, assessed prospectively through June, 2008 by inpatient and outpatient records. The analysis was stratified by sex a priori.
There was a U-shaped relationship between serum urate levels and hip fractures in men. Men in the lowest and the highest urate quartiles (<4.88 and ≥6.88mg/dL respectively) had a significantly higher rate of fractures in unadjusted analysis. However, upon multivariate adjustment, only the HR for hip fracture in highest quartile versus the reference remained significant (HR 1.9; 95% C.I. 1.1, 3.1; p value 0.02). High serum urate levels were not associated with hip fractures in women.
In this large prospective cohort of community-dwelling older adults, increased serum urate levels were associated with an increased risk of hip fractures in men. Further studies are needed to confirm these findings and to understand the mechanisms that underlie them.
Details
- Title: Subtitle
- Serum urate levels and the risk of hip fractures: data from the Cardiovascular Health Study
- Creators
- Tapan Mehta - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, COPetra Bůžková - Department of Biostatistics, University of Washington, Seattle, WA; Department of Epidemiology, University of Washington, Seattle, WAMark J Sarnak - Department of Medicine, Division of Nephrology, Tufts Medical Center, Boston, MAMichel Chonchol - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, COJane A Cauley - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PAErin Wallace - Department of Epidemiology, University of Washington, Seattle, WAHoward A Fink - Geriatric Research Education & Clinical Center, Minneapolis VA Health Care System, Minneapolis, MNJohn Robbins - University of California Davis Medical Center, Sacramento, CADiana Jalal - Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Center, Aurora, CO
- Resource Type
- Journal article
- Publication Details
- Metabolism, clinical and experimental, Vol.64(3), pp.438-446
- DOI
- 10.1016/j.metabol.2014.11.006
- PMID
- 25491429
- PMCID
- PMC4312534
- NLM abbreviation
- Metabolism
- ISSN
- 0026-0495
- eISSN
- 1532-8600
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute (NHLBI), award: HHSN268201200036C, HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, HL080295; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke (NINDS); name: National Institute on Aging (NIA), award: AG023629, 1K23DK088833
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094490102771
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