Journal article
Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes
Journal of diabetes and its complications, Vol.28(3), pp.298-304
05/01/2014
DOI: 10.1016/j.jdiacomp.2013.12.007
PMCID: PMC4004676
PMID: 24461546
Abstract
Hypothesis: Decreased insulin sensitivity (IS) exists in type 1 diabetes. Serum uric acid (SUA), whose concentration is related to renal clearance, predicts vascular complications in type 1 diabetes. SUA is also inversely associated with IS in non-diabetics, but has not been examined in type 1 diabetes. We hypothesized SUA would be associated with reduced IS in adolescents and adults with type 1 diabetes.
Methods: The cross-sectional and longitudinal associations of SUA with IS were investigated in 254 adolescents with type 1 diabetes and 70 without in the Determinants of Macrovascular Disease in Adolescents with Type 1 Diabetes Study, and in 471 adults with type 1 diabetes and 571 without in the Coronary Artery Calcification in Type 1 diabetes (CACTI) study.
Results: SUA was lower in subjects with type 1 diabetes (p < 0.0001), but still remained inversely associated with IS after multivariable adjustments in adolescents (beta +/- SE: -1.99 +/- 0.62, p = 0.001, R-2 = 2%) and adults (beta +/- SE: -0.91 +/- 0.33, p = 0.006, R-2 = 6%) with type 1 diabetes, though less strongly than in nondiabetic controls (adolescents: beta +/- SE: -2.70 +/- 1.19, p = 0.03, R-2 = 15%, adults: beta +/- SE: -5.99 +/- 0.75, p < 0.0001, R-2 = 39%).
Conclusion: We demonstrated a significantly weaker relationship between SUA and reduced IS in subjects with type 1 diabetes than non-diabetic controls. (C) 2014 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes
- Creators
- Petter Bjornstad - University of Colorado Anschutz Medical CampusJanet K. Snell-Bergeon - University of Colorado Anschutz Medical CampusKimberly McFann - Colorado School of Public HealthR. Paul Wadwa - University of Colorado Anschutz Medical CampusMarian Rewers - University of Colorado Anschutz Medical CampusChristopher J. Rivard - University of Colorado Anschutz Medical CampusDiana Jalal - Colorado School of Public HealthMichel B. Chonchol - University of Colorado Anschutz Medical CampusRichard J. Johnson - University of Colorado Anschutz Medical CampusDavid M. Maahs - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes and its complications, Vol.28(3), pp.298-304
- DOI
- 10.1016/j.jdiacomp.2013.12.007
- PMID
- 24461546
- PMCID
- PMC4004676
- NLM abbreviation
- J Diabetes Complications
- ISSN
- 1056-8727
- eISSN
- 1873-460X
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- R01 HL61753; HL79611; HL113029 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 1-10-JF-50 / American Diabetes Association Junior Faculty Award; American Diabetes Association R01HL079611 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) DK075360 / NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 11-2007-694 / Juvenile Diabetes Research Foundation M01RR000051 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 17-2013-313 / JDRF; Juvenile Diabetes Research Foundation UL1TR001082 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) P30 DK57516 / DERC Clinical Investigation Core M01-RR00051 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K23DK075360 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 05/01/2014
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359936102771
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