Journal article
Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: Findings from the Coronary Artery Calcification in Type 1 Diabetes study
Nephrology, dialysis, transplantation, Vol.25(6), pp.1865-1869
06/2010
DOI: 10.1093/ndt/gfp740
PMCID: PMC2902891
PMID: 20064950
Abstract
Background. Recent studies suggest that uric acid is a mediator of diabetic nephropathy. We hypothesized that elevated serum uric acid levels are a strong predictor of albuminuria in patients with type 1 diabetes. Methods. We analyzed data from the Coronary Artery Calcification in Type 1 Diabetes study, a prospective observational study. A stepwise logistic regression model was applied to predict the development of micro- or macroalbuminuria after 6 years of follow-up in 324 participants who had no evidence of micro- or macroalbuminuria at baseline. A P-value <0.1 was used as the criteria for entry into and removal from the model. Results. The following factors were selected in the stepwise multivariate model as predictors of micro- or macroalbuminuria at the 6-year follow-up visit: baseline serum uric acid levels, HbA1c and pre-albuminuria. For every 1-mg/dl increase in serum uric acid levels at baseline, there was an 80% increased risk of developing micro- or macroalbuminuria at 6 years (odds ratio 1.8; 95% confidence interval 1.2, 2.8; P = 0.005). Additional covariates considered in the stepwise model were sex, age, duration of diabetes, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker treatment, waist circumference, waist/hip ratio, body mass index, systolic and diastolic blood pressure, smoking, serum creatinine, cystatin C, high-density lipoprotein cholesterol and triglycerides. Conclusion. Elevated serum uric acid levels are a strong predictor of the development of albuminuria in patients with type 1 diabetes.
Details
- Title: Subtitle
- Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: Findings from the Coronary Artery Calcification in Type 1 Diabetes study
- Creators
- Diana I Jalal - Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USAChristopher J Rivard - Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USARichard J Johnson - Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USADavid M Maahs - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USAKimberly McFann - Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USAMarian Rewers - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USAJanet K Snell-Bergeon - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA
- Resource Type
- Journal article
- Publication Details
- Nephrology, dialysis, transplantation, Vol.25(6), pp.1865-1869
- Publisher
- Oxford University Press
- DOI
- 10.1093/ndt/gfp740
- PMID
- 20064950
- PMCID
- PMC2902891
- ISSN
- 0931-0509
- eISSN
- 1460-2385
- Language
- English
- Date published
- 06/2010
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094715602771
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