Journal article
Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease
Diabetes care, Vol.33(11), pp.2471-2473
11/2010
DOI: 10.2337/dc10-1007
PMCID: PMC2963516
PMID: 20798338
Abstract
To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.
CAC was measured by electron beam tomography at the baseline and at a follow-up 6.0±0.5 years later. The study population included 443 participants with type 1 diabetes and 526 control subjects who were free of diagnosed coronary artery disease at baseline. The presence of renal disease was defined by the presence of albuminuria and/or low glomerular filtration rate.
In subjects without renal disease, serum UA predicted CAC progression (odds ratio 1.30 [95% CI 1.07-1.58], P=0.007) independent of conventional cardiovascular risk factors including diabetes and the presence of metabolic syndrome.
Serum UA levels predict the progression of coronary atherosclerosis and may be useful in identifying who is at risk for vascular disease in the absence of significant chronic kidney disease.
Details
- Title: Subtitle
- Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease
- Creators
- Ticiana C Rodrigues - Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USADavid M MaahsRichard J JohnsonDiana I JalalGregory L KinneyChristopher RivardMarian RewersJanet K Snell-Bergeon
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.33(11), pp.2471-2473
- DOI
- 10.2337/dc10-1007
- PMID
- 20798338
- PMCID
- PMC2963516
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- R01 HL113029 / NHLBI NIH HHS K23 DK075360 / NIDDK NIH HHS R01 HL61753 / NHLBI NIH HHS K23 DK088833 / NIDDK NIH HHS P30 DK57516 / NIDDK NIH HHS R01 HL061753 / NHLBI NIH HHS M01 RR000051 / NCRR NIH HHS R01 HL079611 / NHLBI NIH HHS R01 HL68607 / NHLBI NIH HHS P30 DK057516 / NIDDK NIH HHS R01 HL068607 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/2010
- Academic Unit
- Psychiatry; Nephrology; Internal Medicine
- Record Identifier
- 9984094486302771
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