Journal article
Setting research priorities to improve global newborn health and prevent stillbirths by 2025
Journal of global health, Vol.6(1), pp.010508-010508
06/2016
DOI: 10.7189/jogh.06.010508
PMCID: PMC4576458
PMID: 26401272
Abstract
In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.
We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.
Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.
These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.
Details
- Title: Subtitle
- Setting research priorities to improve global newborn health and prevent stillbirths by 2025
- Creators
- Sachiyo Yoshida - Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, SwitzerlandRobert Clark - Charities, USAPatrick J McNamara - Departments of Paediatrics & Physiology, University of Toronto; Physiology & Experimental Medicine program, Hospital for Sick Children, Toronto, CanadaJosé Martines - Centre for Intervention Science in Maternal and Child Health, Centre for International Health, University of Bergen, NorwayYanfeng Zhang - Department of Integrated Early Childhood Development, Capital Institute of Paediatrics, ChinaJoy E Lawn - London School of Hygiene and Tropical Medicine, London, UK ; Saving Newborn Lives, Save the Children, Washington, USAWei Wang - School of Medical Sciences, Edith Cowan University, Australia and School of Public Health, Capital Medical University, ChinaStephen Wall - Saving Newborn Lives, Save the Children, Washington, USAJoăo Paulo Souza - Department of Social Medicine, Ribeirăo Preto School of Medicine, University of Săo Paulo, BrazilIgor Rudan - Centre for Population Health Sciences and Global Health Academy, The University of Edinburgh Medical School, Scotland, UKSimon Cousens - London School of Hygiene and Tropical Medicine, London, UKPeter Aaby - Bandim Health Project, Indepth Network, Guinea-BissauIshag Adam - Faculty of Medicine, University of Khartoum, SudanRamesh Kant Adhikari - Kathmandu Medical College, NepalNamasivayam Ambalavanan - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USAShams Ei Arifeen - Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, BangladeshDhana Raj Aryal - Department of Neonatology Paropakar Maternity and women's Hospital, NepalNeonatal health research priority setting groupSk Asiruddin - TRAction Bangladesh Project, University Research Co., LLCAbdullah Baqui - Johns Hopkins Bloomberg School of Public Health, USAShinjini Bhatnagar - Pediatric Biology Centre, Translational Health Science and Technology Institute, IndiaVineet Bhandari - Program in Perinatal Research, Yale University School of Medicine, USAAluisio Jd Barros - Centro de Pesquisas Epidemiológicas, Universidade Federal de Pelotas, BrazilSohinee Bhattacharya - University of Aberdeen, UKZulfiqar A Bhutta - Center of Excellence in Women and Child Health, the Aga Khan University, Karachi, PakistanRobert E Black - Institute of International Programs, Johns Hopkins Bloomberg School of Public Health, USAHannah Blencowe - The London School of Hygiene & Tropical Medicine, UKCarl Bose - The University of North Carolina at Chapel Hill School of Medicine, USAJustin Brown - Thrasher Research Fund, USAChristoph Bührer - Department of Neonatology, Charité University Medical Center, GermanyWally Carlo - University of Alabama at Birmingham, USAJose Guilherme Cecatti - Department of Obstetrics and Gynaecology, School of Medical Sciences, University of Campinas, BrazilPo-Yin Cheung - Departments of Pediatrics, Pharmacology & Surgery, University of Alberta, CanadaTim Colbourn - University College London Institute for Global Health, UKAgustin Conde-Agudelo - Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, Maryland and Detroit, Michigan, USAErica Corbett - Independent consultant maternal health research, RwandaAndrew E Czeizel - Foundation for the Community Control of Hereditary Diseases, HungaryAshok Deorari - All India Institute of Medical Sciences, IndiaAbhik Das - Biostatistics and Epidemiology, RTI International, USALouise Tina Day - LAMB Integrated Rural Health & Development, BangladeshUğur Dilmen - Pediatrics and Neonatology, Yıldırım Beyazıt University Medical Faculty, TurkeyCarolyn Deal - Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases National Institute of Health, USAMike English - Nuffield Department of Medicine & Department of Paediatrics, University of Oxford, UK and KEMRi-Wellcome Trust Research Programme, Nairobi, KenyaCyril Engmann - Newborn Health, Family Health Division, The Bill & Melinda Gates Foundation and the University of North Carolina Schools of Medicine and Public Health, USAFabian Esamai - Moi University, School of Medicine, KenyaCaroline Fall - International Paediatric Epidemiology; Affiliations: Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, UKDonna M Ferriero - Department of Pediatrics, UCSF Benioff Children's Hospital, USAPeter Gisore - School of Medicine, Child Health and Pediatrics, Moi University, KenyaTabish Hazir - Children's Hospital, Pakistan Institute of Medical Sciences, PakistanRosemary D Higgins - Eunice Kennedy Shriver NICHD Neonatal Research Network, Pregnancy and Perinatology, Branch, National Institute of Health, USACaroline Se Homer - Centre for Midwifery, Child and Family Health, University of Technology, Sydney, AustraliaD E Hoque - Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, BangladeshLorentz Irgens - University of Bergen and Norwegian Institute of Public Health, NorwayM T Islam - Japan International Cooperation Agency (JICA), BangladeshJoseph de Graft-Johnson - Save the Children, USAMartias Alice Joshua - Zomba Central Hospital, Ministry of Health, MalawiWilliam Keenan - Saint Louis University, USASoofia Khatoon - Paediatrics and Head of Department Shaheed Suhrawardy Medical College, BangladeshEve M Lackritz - Global Alliance to Prevent Prematurity and Stillbirth (GAPPS), USATina Lavender - University of Manchester School of Nursing Midwifery & Social Work, University of Manchester, UKMichael S Kramer - Departments of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University Faculty of Medicine, Montreal, Quebec, CanadaHelle Kieler - Centre for Pharmacoepidemiology, Karolinska Institute, SwedenLaurensia Lawintono - Indonesian Midwives Association, IndonesiaRichard Luhanga - Save the Children, MalawiDavid Marsh - Save the Children, USADouglas McMillan - Department of Paediatrics, Dalhousie University, CanadaBen Willem J Mol - Department of Obstetrics and Gynaecology, Academic Medical Centre Amsterdam, the NetherlandsElizabeth Molyneux - Paediatrics and Child Health, College of Medicine MalawiG K Mukasa - International Baby Food Action Network, UgandaMiriam Mutabazi - STRIDES for Family Health, Management Sciences for Health, UgandaLuis Carlos Nacul - Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UKMargaret Nakakeeto - Kampala Children's Hospital Limited and Childhealth Advocacy International, UgandaIndira Narayanan - United States Agency for International Development /Maternal and Child Health Integrated Program, USABolajoko Olusanya - Centre for Healthy Start Initiative, NigeriaDavid Osrin - Wellcome Trust Senior Research Fellow in Clinical Science, Institute for Global Health, University College London, UKVinod Paul - All India Institute of Medical Sciences, IndiaChristian Poets - University of Tubingen, GermanyUma M Reddy - Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, USAMathuram Santosham - Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, USARubayet Sayed - Save the Children, BangladeshNatalia E Schlabritz-Loutsevitch - Department of Obstetrics and Gynecology, University of Tennessee Health Science Center, USANalini Singhal - University of Calgary, CanadaMary Alice Smith - Environmental Health Science Department, University of Georgia, USAPeter G Smith - Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UKSajid Soofi - Department of Pediatrics & Child Health, Women & Child Health Division, Aga Khan University, PakistanCatherine Y Spong - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USAShahin Sultana - National Institute of Population Research and Training (NIPORT), Ministry of Health and Family Welfare, BangladeshAntoinette Tshefu - Kinshasa School of Public Health, School of Medicine, University of Kinshasa, Democratic Republic of CongoFrank van Bel - Department of Neonatology, University of Utrecht, the NetherlandsLauren Vestewig Gray - Institute for Global Health Technologies Rice University, USAPeter Waiswa - Division of Global Health, Karolinska Institutet, SwedenSarah LA Williams - Save the Children UKLinda Wright - Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, USAAnita Zaidi - Aga Khan University, PakistanNanbert Zhong - Developmental Genetics Laboratory, New York State Institute for Basic Research in Developmental Disabilities, USAIsabel Zuniga - Médecins sans Frontičres, BelgiumRajiv Bahl - Department of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerlandneonatal health research priority setting group
- Resource Type
- Journal article
- Publication Details
- Journal of global health, Vol.6(1), pp.010508-010508
- DOI
- 10.7189/jogh.06.010508
- PMID
- 26401272
- PMCID
- PMC4576458
- NLM abbreviation
- J Glob Health
- ISSN
- 2047-2978
- eISSN
- 2047-2986
- Grant note
- MR/K012126/1 / Medical Research Council 091561 / Wellcome Trust 001 / World Health Organization
- Language
- English
- Date published
- 06/2016
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093312102771
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