Journal article
Several types of adherent cells elaborate a dialyzable lymphopoietic cofactor (abelson growth promoter)
The International Journal of Cell Cloning, Vol.8(6), pp.392-408
1990
DOI: 10.1002/stem.5530080643
PMID: 2273295
Abstract
We have cloned a stromal cell from mouse bone marrow selected on the basis of its ability to promote the growth of an Abelson virus‐transformed pre‐B cell line. These stromal cells have smooth muscle features, and the ultrafiltrate of stromal cell‐conditioned medium has proliferative effects on all feeder layer‐responsive mouse pre‐B cell lines tested, as well as on normal pre‐B cells. One of these low MW substances is a protease‐resistant factor with an MW of approximately 450 Da which we designate Abelson Growth Promoter (AGP). AGP was initially characterized as an activity which promotes the growth of Abelson virus‐transformed mouse pre‐B cells, but it also promotes the growth of a fas‐transformed pre‐B cell line as a single agent and in synergistic fashion with recombinant interleukin (IL) 7. AGP as a single agent has no effect on normal pre‐B cells, which have a brisk response to IL‐7. In contrast, transformed pre‐B cells display a blunted response to IL‐7. We propose that AGP plays a role in normal lymphopoiesis by expanding clones of pre‐B cells which have been activated by other stromal cell‐derived signals, such as IL‐7, and directly promotes the growth of nascently transformed pre‐B cells.
Details
- Title: Subtitle
- Several types of adherent cells elaborate a dialyzable lymphopoietic cofactor (abelson growth promoter)
- Creators
- Michael MuirheadRandall DavisThomas J WaldschmidtLaynez AckermannRichard C SchwartzGreg PalumboR. G Smith
- Resource Type
- Journal article
- Publication Details
- The International Journal of Cell Cloning, Vol.8(6), pp.392-408
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- DOI
- 10.1002/stem.5530080643
- PMID
- 2273295
- ISSN
- 0737-1454
- eISSN
- 1549-4918
- Number of pages
- 17
- Language
- English
- Date published
- 1990
- Academic Unit
- Pathology
- Record Identifier
- 9984047618902771
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