Journal article
Severe Arboviral Neuroinvasive Disease in Patients on Rituximab Therapy: A Review
Clinical infectious diseases, Vol.76(6), pp.1142-1148
03/15/2023
DOI: 10.1093/cid/ciac766
PMCID: PMC10011006
PMID: 36103602
Abstract
With increasing use of rituximab and other B-cell depleting monoclonal antibodies for multiple indications, infectious complications are being recognized. We summarize clinical findings of patients on rituximab with arboviral diseases identified through literature review or consultation with the Centers for Disease Control and Prevention. We identified 21 patients on recent rituximab therapy who were diagnosed with an arboviral disease caused by West Nile, tick-borne encephalitis, eastern equine encephalitis, Cache Valley, Jamestown Canyon, and Powassan viruses. All reported patients had neuroinvasive disease. The diagnosis of arboviral infection required molecular testing in 20 (95%) patients. Median illness duration was 36 days (range, 12 days to 1 year), and 15/19 (79%) patients died from their illness. Patients on rituximab with arboviral disease can have a severe or prolonged course with an absence of serologic response. Patients should be counseled about mosquito and tick bite prevention when receiving rituximab and other B-cell depleting therapies
Details
- Title: Subtitle
- Severe Arboviral Neuroinvasive Disease in Patients on Rituximab Therapy: A Review
- Creators
- Ronak K Kapadia - University of Colorado DenverJ Erin Staples - Centers for Disease Control and PreventionChristine M Gill - Roy J. and Lucille A. Carver College of MedicineMarc Fischer - Centers for Disease Control and PreventionEzza Khan - Hunterdon Infectious Disease Specialists , Flemington, NJ USAJaneen J Laven - Centers for Disease Control and PreventionAmanda Panella - Centers for Disease Control and PreventionJason O Velez - Centers for Disease Control and PreventionHolly R Hughes - Centers for Disease Control and PreventionAaron Brault - Centers for Disease Control and PreventionDaniel M Pastula - University of Colorado DenverCarolyn V Gould - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.76(6), pp.1142-1148
- DOI
- 10.1093/cid/ciac766
- PMID
- 36103602
- PMCID
- PMC10011006
- NLM abbreviation
- Clin Infect Dis
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Electronic publication date
- 09/14/2022
- Date published
- 03/15/2023
- Academic Unit
- Neurology
- Record Identifier
- 9984303263202771
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