Journal article
Severe Asthma: Lessons Learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program
American journal of respiratory and critical care medicine, Vol.185(4), pp.356-362
02/15/2012
DOI: 10.1164/rccm.201107-1317PP
PMCID: PMC3297096
PMID: 22095547
Abstract
The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure–function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.
Details
- Title: Subtitle
- Severe Asthma: Lessons Learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program
- Creators
- Nizar N Jarjour - University of Wisconsin, Madison, WisconsinSerpil C Erzurum - University of Wisconsin, Madison, WisconsinEugene R Bleecker - University of Wisconsin, Madison, WisconsinWilliam J Calhoun - University of Wisconsin, Madison, WisconsinMario Castro - University of Wisconsin, Madison, WisconsinSuzy A. A Comhair - University of Wisconsin, Madison, WisconsinKian Fan Chung - University of Wisconsin, Madison, WisconsinDouglas Curran-Everett - University of Wisconsin, Madison, WisconsinRaed A Dweik - University of Wisconsin, Madison, WisconsinSean B Fain - University of Wisconsin, Madison, WisconsinAnne M Fitzpatrick - University of Wisconsin, Madison, WisconsinBenjamin M Gaston - University of Wisconsin, Madison, WisconsinElliot Israel - University of Wisconsin, Madison, WisconsinAnnette Hastie - University of Wisconsin, Madison, WisconsinEric A Hoffman - University of Wisconsin, Madison, WisconsinFernando Holguin - University of Wisconsin, Madison, WisconsinBruce D Levy - University of Wisconsin, Madison, WisconsinDeborah A Meyers - University of Wisconsin, Madison, WisconsinWendy C Moore - University of Wisconsin, Madison, WisconsinStephen P Peters - University of Wisconsin, Madison, WisconsinRonald L Sorkness - University of Wisconsin, Madison, WisconsinW. Gerald Teague - University of Wisconsin, Madison, WisconsinSally E Wenzel - University of Wisconsin, Madison, WisconsinWilliam W Busse - University of Wisconsin, Madison, Wisconsin
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.185(4), pp.356-362
- DOI
- 10.1164/rccm.201107-1317PP
- PMID
- 22095547
- PMCID
- PMC3297096
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- American Thoracic Society
- Language
- English
- Date published
- 02/15/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984051730302771
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