Journal article
Severe Influenza in 33 US Hospitals, 2013-2014: Complications and Risk Factors for Death in 507 Patients
Infection control and hospital epidemiology, Vol.36(11), pp.1251-1260
11/2015
DOI: 10.1017/ice.2015.170
PMID: 26224364
Abstract
Influenza A (H1N1) pdm09 became the predominant circulating strain in the United States during the 2013-2014 influenza season. Little is known about the epidemiology of severe influenza during this season.
A retrospective cohort study of severely ill patients with influenza infection in intensive care units in 33 US hospitals from September 1, 2013, through April 1, 2014, was conducted to determine risk factors for mortality present on intensive care unit admission and to describe patient characteristics, spectrum of disease, management, and outcomes.
A total of 444 adults and 63 children were admitted to an intensive care unit in a study hospital; 93 adults (20.9%) and 4 children (6.3%) died. By logistic regression analysis, the following factors were significantly associated with mortality among adult patients: older age (>65 years, odds ratio, 3.1 [95% CI, 1.4-6.9], P=.006 and 50-64 years, 2.5 [1.3-4.9], P=.007; reference age 18-49 years), male sex (1.9 [1.1-3.3], P=.031), history of malignant tumor with chemotherapy administered within the prior 6 months (12.1 [3.9-37.0], P<.001), and a higher Sequential Organ Failure Assessment score (for each increase by 1 in score, 1.3 [1.2-1.4], P<.001).
Risk factors for death among US patients with severe influenza during the 2013-2014 season, when influenza A (H1N1) pdm09 was the predominant circulating strain type, shifted in the first postpandemic season in which it predominated toward those of a more typical epidemic influenza season.
Details
- Title: Subtitle
- Severe Influenza in 33 US Hospitals, 2013-2014: Complications and Risk Factors for Death in 507 Patients
- Creators
- Nirav S Shah - 1Department of Medicine,University of Chicago,Chicago,IllinoisJared A Greenberg - 1Department of Medicine,University of Chicago,Chicago,IllinoisMoira C McNulty - 1Department of Medicine,University of Chicago,Chicago,IllinoisKevin S Gregg - 2Department of Medicine,University of Michigan Medical School,Ann Arbor,MichiganJames Riddell - 2Department of Medicine,University of Michigan Medical School,Ann Arbor,MichiganJulie E Mangino - 3Department of Medicine,Ohio State University Wexner Medical Center,Columbus,OhioDevin M Weber - 3Department of Medicine,Ohio State University Wexner Medical Center,Columbus,OhioCourtney L Hebert - 3Department of Medicine,Ohio State University Wexner Medical Center,Columbus,OhioNatalie S Marzec - 5Department of Medicine,University of Colorado Denver,Denver,ColoradoMichelle A Barron - 5Department of Medicine,University of Colorado Denver,Denver,ColoradoFredy Chaparro-Rojas - 6Department of Medicine,Vidant Medical Center,Greenville,North CarolinaAlejandro Restrepo - 7Department of Medicine,Baylor College of Medicine,Houston,TexasVagish Hemmige - 7Department of Medicine,Baylor College of Medicine,Houston,TexasKunatum Prasidthrathsint - 8Department of Medicine,University of Iowa Hospitals and Clinics,Iowa City,IowaSandra Cobb - 8Department of Medicine,University of Iowa Hospitals and Clinics,Iowa City,IowaLoreen Herwaldt - 8Department of Medicine,University of Iowa Hospitals and Clinics,Iowa City,IowaVanessa Raabe - 9Department of Pediatrics,University of California San Diego and Rady Children's Hospital San Diego,San Diego,CaliforniaChristopher R Cannavino - 9Department of Pediatrics,University of California San Diego and Rady Children's Hospital San Diego,San Diego,CaliforniaAndrea Green Hines - 10Department of Medicine,University of Nebraska Medical Center,Omaha,NebraskaSara H Bares - 10Department of Medicine,University of Nebraska Medical Center,Omaha,NebraskaPhilip B Antiporta - 11Department of Medicine,Loyola University Medical Center,Maywood,IllinoisTonya Scardina - 13Department of Pharmacy,Loyola University Medical Center,Maywood,IllinoisUrsula Patel - 14Department of Pharmacy,Edward Hines VA Hospital,Maywood,IllinoisGail Reid - 11Department of Medicine,Loyola University Medical Center,Maywood,IllinoisParvin Mohazabnia - 15Department of Medicine,University of Texas Southwestern Medical Center,Dallas,TexasSuresh Kachhdiya - 15Department of Medicine,University of Texas Southwestern Medical Center,Dallas,TexasBinh-Minh Le - 15Department of Medicine,University of Texas Southwestern Medical Center,Dallas,TexasConnie J Park - 16Department of Medicine,Montefiore Medical Center/Albert Einstein College of Medicine,Bronx,New YorkBelinda Ostrowsky - 16Department of Medicine,Montefiore Medical Center/Albert Einstein College of Medicine,Bronx,New YorkAri Robicsek - 1Department of Medicine,University of Chicago,Chicago,IllinoisBecky A Smith - 17Department of Medicine,Northshore University HealthSystem,Evanston,IllinoisJeanmarie Schied - 18Department of Pediatrics,University of Chicago,Chicago,IllinoisMicah M Bhatti - 18Department of Pediatrics,University of Chicago,Chicago,IllinoisStockton Mayer - 19Department of Medicine,University of Illinois at Chicago,Chicago,IllinoisMonica Sikka - 19Department of Medicine,University of Illinois at Chicago,Chicago,IllinoisIvette Murphy-Aguilu - 19Department of Medicine,University of Illinois at Chicago,Chicago,IllinoisPriti Patwari - 21Department of Medicine,Community Care Networks,Munster,IndianaShira R Abeles - 22Department of Medicine,University of California San Diego,San Diego,CaliforniaFrancesca J Torriani - 22Department of Medicine,University of California San Diego,San Diego,CaliforniaZainab Abbas - 23Department of Medicine,Methodist Hospitals,Merrillville,IndianaSophie Toya - 23Department of Medicine,Methodist Hospitals,Merrillville,IndianaKatherine Doktor - 24Department of Medicine,University of Miami/Jackson Health System,Miami,FloridaAnindita Chakrabarti - 24Department of Medicine,University of Miami/Jackson Health System,Miami,FloridaSusanne Doblecki-Lewis - 24Department of Medicine,University of Miami/Jackson Health System,Miami,FloridaDavid J Looney - 25Department of Medicine,VA San Diego/University of California San Diego,San Diego,CaliforniaMichael Z David - 1Department of Medicine,University of Chicago,Chicago,Illinois
- Resource Type
- Journal article
- Publication Details
- Infection control and hospital epidemiology, Vol.36(11), pp.1251-1260
- DOI
- 10.1017/ice.2015.170
- PMID
- 26224364
- ISSN
- 0899-823X
- eISSN
- 1559-6834
- Grant note
- K23 AI095361 / NIAID NIH HHS
- Language
- English
- Date published
- 11/2015
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984094328902771
Metrics
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