Journal article
Severe Methotrexate Toxicity Following a Capizzi Cycle in an Obese Adolescent With Acute Lymphoblastic Leukemia and Hepatic Steatosis
Journal of pediatric hematology/oncology, Vol.46(1), pp.e107-e110
01/01/2024
DOI: 10.1097/MPH.0000000000002771
PMID: 37916829
Abstract
Methotrexate is a major component of pediatric leukemia treatment. While toxicities are common after high-dose methotrexate, escalating dose methotrexate (Capizzi methotrexate) is typically well-tolerated. We report an adolescent Hispanic female with pre-B acute lymphoblastic leukemia, preexisting obesity and hepatic steatosis who developed severe multiorgan failure following an escalating dose of methotrexate with delayed methotrexate excretion of 11 days. We identified one similar report in an obese adult; however, this case is the first to our knowledge involving a pediatric patient. With the rising incidence of obesity and associated comorbidities among children and adolescents with leukemia, attention to potential risks for this population is warranted.
Details
- Title: Subtitle
- Severe Methotrexate Toxicity Following a Capizzi Cycle in an Obese Adolescent With Acute Lymphoblastic Leukemia and Hepatic Steatosis
- Creators
- Julie M. Fischer - The University of Texas Health Science Center at San AntonioOranooj Lertkovit - Navamindradhiraj UniversityScott C. Howard - University of Tennessee Health Science CenterChatchawin Assanasen - The University of Texas Health Science Center at San AntonioArchie Bleyer - Oregon Health & Science University
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric hematology/oncology, Vol.46(1), pp.e107-e110
- DOI
- 10.1097/MPH.0000000000002771
- PMID
- 37916829
- NLM abbreviation
- J Pediatr Hematol Oncol
- ISSN
- 1077-4114
- eISSN
- 1536-3678
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Language
- English
- Date published
- 01/01/2024
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984966848902771
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