Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines

H. Bryant Nguyen; Emanuel P. Rivers; Fredrick M. Abrahamian; Gregory J. Moran; Edward Abraham; Stephen Trzeciak; David T. Huang; Tiffany Osborn; Dennis Stevens; David A. Talan; Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group

doi:10.1016/j.annemergmed.2006.02.015

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Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines

Journal article

Peer reviewed

Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines

H. Bryant Nguyen, Emanuel P. Rivers, Fredrick M. Abrahamian, Gregory J. Moran, Edward Abraham, Stephen Trzeciak, David T. Huang, Tiffany Osborn, Dennis Stevens, David A. Talan, …

Annals of emergency medicine, Vol.48(1), pp.54.e1-54.e1

2006

DOI: 10.1016/j.annemergmed.2006.02.015

PMID: 16781920

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Abstract

Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma. Recent studies have led to a better understanding of the pathogenic mechanisms and the development of new or newly applied therapies. These therapies place early and aggressive management of severe sepsis and septic shock as integral to improving outcome. This independent review of the literature examines the recent pathogenic, diagnostic, and therapeutic advances in severe sepsis and septic shock for adults, with particular relevance to emergency practice. Recommendations are provided for therapies that have been shown to improve outcomes, including early goal-directed therapy, early and appropriate antimicrobials, source control, recombinant human activated protein C, corticosteroids, and low tidal volume mechanical ventilation.

Details

Title: Subtitle: Severe Sepsis and Septic Shock: Review of the Literature and Emergency Department Management Guidelines
Creators: H. Bryant Nguyen - Loma Linda University
Emanuel P. Rivers - Henry Ford Hospital
Fredrick M. Abrahamian - Olive View-UCLA Medical Center
Gregory J. Moran - Olive View-UCLA Medical Center
Edward Abraham - University of Colorado Denver
Stephen Trzeciak - Cooper University Hospital
David T. Huang - University of Pittsburgh
Tiffany Osborn - University of Virginia
Dennis Stevens - Boise VA Medical Center
David A. Talan - Olive View-UCLA Medical Center
Emergency Department Sepsis Education Program and Strategies to Improve Survival (ED-SEPSIS) Working Group
Resource Type: Journal article
Publication Details: Annals of emergency medicine, Vol.48(1), pp.54.e1-54.e1
Publisher: Mosby, Inc
DOI: 10.1016/j.annemergmed.2006.02.015
PMID: 16781920
ISSN: 0196-0644
eISSN: 1097-6760
Language: English
Date published: 2006
Academic Unit: Emergency Medicine; Internal Medicine
Record Identifier: 9984296967602771

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