Journal article
Severe erythema multiforme responding to interferon alfa
Journal of the American Academy of Dermatology, Vol.54(2 Suppl), pp.S18-S21
02/2006
DOI: 10.1016/j.jaad.2005.04.042
PMID: 16427985
Abstract
Erythema multiforme (EM) is a targetoid eruption with interface pathology often triggered by a hypersensitivity response to a variety of infections, most commonly herpes simplex virus. Hepatitis C virus is rarely associated with EM. We present a 37-year-old man with an 8-year history of severe EM unresponsive to valacyclovir, acitretin, and cyclosporin, and marginally responsive to high-dose prednisone. The eruption had cleared 6 years previously during treatment with interferon for his concurrent hepatitis C virus. Although his viral titer was undetectable, we initiated therapy with interferon and ribavirin. The patient responded dramatically within 2 months and remained clear of EM after 1 year of continued interferon therapy. This is the third case reported in the world literature documenting a response of EM to interferon, and the first case in which hepatitis C virus was undetectable in serum prior to interferon therapy.
Details
- Title: Subtitle
- Severe erythema multiforme responding to interferon alfa
- Creators
- Pedram Geraminejad - Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAHobart W WallingMichael D VoigtMary Seabury Stone
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Dermatology, Vol.54(2 Suppl), pp.S18-S21
- DOI
- 10.1016/j.jaad.2005.04.042
- PMID
- 16427985
- NLM abbreviation
- J Am Acad Dermatol
- ISSN
- 0190-9622
- eISSN
- 1097-6787
- Publisher
- United States
- Language
- English
- Date published
- 02/2006
- Academic Unit
- Dermatology; Gastroenterology and Hepatology; Pathology; Internal Medicine
- Record Identifier
- 9984025667402771
Metrics
13 Record Views