Severe hypercalcaemia from ectopic intact parathyroid hormone secretion treated with continuous renal replacement therapy in a patient with two malignancies

Nathaniel Hocker; Maria Story; Alysa Lerud; Sarat Kuppachi

doi:10.1136/bcr-2021-242172

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Severe hypercalcaemia from ectopic intact parathyroid hormone secretion treated with continuous renal replacement therapy in a patient with two malignancies

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Severe hypercalcaemia from ectopic intact parathyroid hormone secretion treated with continuous renal replacement therapy in a patient with two malignancies

Nathaniel Hocker, Maria Story, Alysa Lerud and Sarat Kuppachi

BMJ case reports, Vol.14(6), p.e242172

06/29/2021

DOI: 10.1136/bcr-2021-242172

PMCID: PMC8245462

PMID: 34187797

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245462View

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Abstract

We present a 61-year-old Caucasian woman with endometroid carcinoma as well as a poorly differentiated adenocarcinoma who developed severe hypercalcaemia in the setting of an elevated intact parathyroid hormone. The patient was hospitalised twice for her condition. During her first hospitalisation, she was diagnosed with an endometroid carcinoma and hypercalcaemia. With medical management, she had a normal calcium level on discharge. She presented 3 weeks later with hypercalcaemia and encephalopathy. This time her hypercalcaemia was refractory to medical management, and required continuous renal replacement therapy (CRRT) to normalise her serum calcium. Lung biopsy revealed a poorly differentiated adenocarcinoma, suspicious for pancreatic primary. Due to her poor prognosis, rapid elevation of calcium with each attempt to discontinue CRRT, and the poor options for treatment of her cancers, she elected to pursue hospice care.

Details

Title: Subtitle: Severe hypercalcaemia from ectopic intact parathyroid hormone secretion treated with continuous renal replacement therapy in a patient with two malignancies
Creators: Nathaniel Hocker - University of Iowa Hospitals and Clinics
Maria Story - University of Iowa Hospitals and Clinics
Alysa Lerud - University of Iowa Hospitals and Clinics
Sarat Kuppachi - University of Iowa
Resource Type: Journal article
Publication Details: BMJ case reports, Vol.14(6), p.e242172
DOI: 10.1136/bcr-2021-242172
PMID: 34187797
PMCID: PMC8245462
ISSN: 1757-790X
eISSN: 1757-790X
Language: English
Date published: 06/29/2021
Academic Unit: Physician Assistant Studies; Stead Family Department of Pediatrics; Nephrology; Internal Medicine
Record Identifier: 9984359946702771

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