Severe obesity, heart disease, and death among white, African American, and Hispanic postmenopausal women

Kathleen M McTigue; Yue-Fang Chang; Charles Eaton; Lorena Garcia; Karen C Johnson; Cora E Lewis; Simin Liu; Rachel H Mackey; Jennifer Robinson; Milagros C Rosal; Linda Snetselaar; Alice Valoski; Lewis H Kuller

doi:10.1002/oby.20224

Back

Severe obesity, heart disease, and death among white, African American, and Hispanic postmenopausal women

Journal article

Peer reviewed

Severe obesity, heart disease, and death among white, African American, and Hispanic postmenopausal women

Kathleen M McTigue, Yue-Fang Chang, Charles Eaton, Lorena Garcia, Karen C Johnson, Cora E Lewis, Simin Liu, Rachel H Mackey, Jennifer Robinson, Milagros C Rosal, …

Obesity (Silver Spring, Md.), Vol.22(3), pp.801-810

03/2014

DOI: 10.1002/oby.20224

PMID: 24493096

View Online

Abstract

To compare mortality, nonfatal coronary heart disease (CHD), and congestive heart failure (CHF) risk across BMI categories in white, African American, and Hispanic women, with a focus on severe obesity (BMI ≥ 40), and examine heterogeneity in weight-related CHD risk. Among 156,775 Women's Health Initiative observational study and clinical trial participants (September 1993-12 September 2005), multivariable Cox models estimated relative risk for mortality, CHD, and CHF. CHD incidence was calculated by anthropometry, race, and cardiovascular risk factors (CVRF). Mortality, nonfatal CHD, and CHF incidence generally rose with BMI category. For severe obesity versus normal BMI, hazard ratios (HRs, 95% confidence interval) for mortality were 1.97 (1.77-2.20) in white, 1.55 (1.20-2.00) in African American, and 2.59 (1.55-4.31) in Hispanic women; for CHD, HRs were 2.05 (1.80-2.35), 2.24 (1.57-3.19), and 2.95 (1.60-5.41) respectively; for CHF, HRs were 5.01 (4.33-5.80), 3.60 (2.30-5.62), and 6.05 (2.49-14.69). CVRF variation resulted in substantial variation in CHD rates across BMI categories, even in severe obesity. CHD incidence was similar by race/ethnicity when differences in BMI or CVRF were accounted for. Severe obesity increases mortality, nonfatal CHD, and CHF risk in women of diverse race/ethnicity. CVRF heterogeneity contributes to variation in CHD incidence even in severe obesity.

African Americans

Body Mass Index

Follow-Up Studies

Humans

Middle Aged

Risk Factors

Hispanic Americans

Hormones - therapeutic use

Proportional Hazards Models

European Continental Ancestry Group

Incidence

Randomized Controlled Trials as Topic

Heart Diseases - epidemiology

Calcium, Dietary - administration & dosage

Postmenopause

Female

Vitamin D - administration & dosage

Aged

Dietary Supplements

Obesity, Morbid - epidemiology

Details

Title: Subtitle: Severe obesity, heart disease, and death among white, African American, and Hispanic postmenopausal women
Creators: Kathleen M McTigue - University of Pittsburgh Departments of Medicine & Public Health, Pittsburgh, Pennsylvania, USA
Yue-Fang Chang
Charles Eaton
Lorena Garcia
Karen C Johnson
Cora E Lewis
Simin Liu - University of California, Los Angeles
Rachel H Mackey
Jennifer Robinson
Milagros C Rosal
Linda Snetselaar
Alice Valoski
Lewis H Kuller
Resource Type: Journal article
Publication Details: Obesity (Silver Spring, Md.), Vol.22(3), pp.801-810
DOI: 10.1002/oby.20224
PMID: 24493096
NLM abbreviation: Obesity (Silver Spring)
ISSN: 1930-739X
eISSN: 1930-739X
Publisher: United States
Grant note: K08 DK067192 / NIDDK NIH HHS 1 K08 DK067192-01 / NIDDK NIH HHS
Language: English
Date published: 03/2014
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995155502771

Metrics

54 Record Views

45 Times Cited - Web of Science

See more details