Journal article
Severe obesity is associated with liver disease severity in pediatric non-alcoholic fatty liver disease
Pediatric obesity, Vol.15(2), pp.e12581-n/a
02/2020
DOI: 10.1111/ijpo.12581
PMID: 31657145
Abstract
Background Paediatric non-alcoholic fatty liver disease (NAFLD) is highly prevalent among children with obesity. The primary objective of this study was determining whether obesity severity is associated with NAFLD severity. By using paediatric classifications for severe obesity, clinicians may be able to better risk stratify patients, which in turn would guide more effective management and treatment. Methods Retrospective cohort study including patients followed at Cincinnati Children's Medical Center for NAFLD. Patients were categorized as overweight or class I, II, III obese based on established body mass index (BMI) cut-offs. Liver disease severity was determined using biochemical, imaging (magnetic resonance elastography [MRE]), and histologic evidence of liver injury. Results Three cohorts were studied individually based on the method used to assess disease severity (biochemical n = 767, imaging n = 366, and histology n = 249). Between the three cohorts, there were significant differences in age, proportion of patients with class II and class III obesity, and serum alanine transaminase (ALT) levels. In the biochemistry cohort, the odds of having ALT > 80 U/L were highest in patients with class III obesity (P = .026). In the imaging cohort, liver stiffness was significantly different between BMI groups of patients (P = .001). In the histology cohort, those with class III obesity had significantly higher odds of NAFLD activity score (NAS) >= 5 (P = .012). Discussion Obesity severity is associated with liver disease severity. Patients with more severe obesity are more likely to have more advanced liver disease, a finding that can assist in risk stratification, as well as monitoring and treatment approaches.
Details
- Title: Subtitle
- Severe obesity is associated with liver disease severity in pediatric non-alcoholic fatty liver disease
- Creators
- Aradhna Seth - University of CincinnatiSarah Orkin - Cincinnati Children's Hospital Medical CenterToshifumi Yodoshi - Cincinnati Children's Hospital Medical CenterChunyan Liu - Cincinnati Children's Hospital Medical CenterLin Fei - Cincinnati Children's Hospital Medical CenterJennifer Hardy - Cincinnati Children's Hospital Medical CenterAndrew T. Trout - Cincinnati Children's Hospital Medical CenterAna-Catalina Arce Clachar - University of CincinnatiKristin Bramlage - Cincinnati Children's Hospital Medical CenterStavra Xanthakos - Cincinnati Children's Hospital Medical CenterMarialena Mouzaki - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric obesity, Vol.15(2), pp.e12581-n/a
- DOI
- 10.1111/ijpo.12581
- PMID
- 31657145
- ISSN
- 2047-6302
- eISSN
- 2047-6310
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- T32DK007727 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01 DK061732; T32 DK007727 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 02/2020
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214108602771
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