Journal article
Severe occlusive carotid artery disease : Hemodynamic assessment by MR perfusion imaging in symptomatic patients
American journal of neuroradiology : AJNR, Vol.20(1), pp.43-51
1999
PMID: 9974057
Abstract
BACKGROUND AND PURPOSE: Cerebral hemodynamic status has been reported to influence the occurrence and outcome of acute stroke. The purpose of this study was to assess hemodynamic compromise in symptomatic patients with severe occlusive disease of the carotid artery by the use of echo-planar perfusion imaging. METHODS: Spin-echo echo-planar perfusion imaging was performed in 11 patients (two had bilateral disease) with severe stenosis or occlusion of the carotid artery who had experienced either a recent transient ischemic attack or minor stroke. Relative cerebral blood volume (rCBV) maps and relative mean transit time (rMTT) maps were generated from the time- concentration curve. Findings on T2-weighted images, angiograms, rCBV maps, and rMTT maps were compared and assessed qualitatively and quantitatively. RESULTS: Although the abnormalities on T2-weighted images were absent, minimal, and/or unrelated to the degree of stenosis or collateral circulation, rMTT maps showed much larger and more distinct perfusion abnormalities along the vascular distribution of the affected vessels in all 13 vascular territories of the 11 patients. Despite obvious abnormalities on rMTT maps, none of the patients had evidence of decreased rCBV in the affected brain tissue (increased in three, normal in eight). A statistically significant difference in rMTT values was found between the affected and unaffected brain tissue, whereas no significant difference was seen in rCBV values. CONCLUSION: Echo-planar perfusion imaging is a noninvasive and rapid method for evaluating the hemodynamics in severe occlusive carotid artery disease and the compensatory vascular changes, and it may be useful in patient management.
Details
- Title: Subtitle
- Severe occlusive carotid artery disease : Hemodynamic assessment by MR perfusion imaging in symptomatic patients
- Creators
- M MAEDA - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United StatesW. T. C YUH - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United StatesT UEDA - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United StatesJ. E MALEY - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United StatesD. L CROSBY - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United StatesM.-W ZHU - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United StatesV. A MAGNOTTA - Department of Radiology, The University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- American journal of neuroradiology : AJNR, Vol.20(1), pp.43-51
- Publisher
- American Society of Neuroradiology; Oak Brook, IL
- PMID
- 9974057
- ISSN
- 0195-6108
- eISSN
- 1936-959X
- Language
- English
- Date published
- 1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute; Otolaryngology
- Record Identifier
- 9984051709202771
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