Journal article
Sex Differences in Outcomes of Late-Window Endovascular Stroke Therapy
Stroke (1970), Vol.55(2), pp.278-287
02/2024
DOI: 10.1161/STROKEAHA.123.045015
PMID: 38252759
Abstract
The association between sex and outcome after endovascular thrombectomy of acute ischemic stroke is unclear. The aim of this study was to compare the clinical and safety outcomes between men and women treated with endovascular thrombectomy in the late 6-to-24-hour window period.
This multicenter, retrospective observational cohort study included consecutive patients who underwent endovascular thrombectomy of anterior circulation stroke in the late window from 66 clinical sites in 10 countries from January 2014 to May 2022. The primary outcome was the 90-day ordinal modified Rankin Scale score. Secondary outcomes included 90-day functional independence (FI), return of Rankin (RoR) to prestroke baseline, FI or RoR, symptomatic intracranial hemorrhage, and mortality. Multivariable and inverse probability of treatment weighting methods were used. We explored the interaction of sex with baseline characteristics on the outcomes ordinal modified Rankin Scale and FI or RoR.
Of 1932 patients, 1055 were women and 877 were men. Women were older (77 versus 69 years), had higher rates of atrial fibrillation, hypertension, and greater prestroke disability, but there was no difference in baseline National Institutes of Health Stroke Scale score. Inverse probability of treatment weighting analysis showed no difference between women and men in ordinal modified Rankin Scale (odds ratio, 0.98 [95% CI, 0.79-1.21]), FI or RoR (odds ratio, 0.98 [95% CI, 0.78-1.22]), severe disability or mortality (odds ratio, 0.99 [95% CI, 0.80-1.23]). The multivariable analysis of the above end points was concordant. There were no interactions between baseline characteristics and sex on the outcomes of ordinal modified Rankin Scale and FI or RoR.
In late presenting patients with anterior circulation stroke treated with endovascular thrombectomy in the 6 to 24-hour window, there was no difference in clinical or safety outcomes between men and women.
Details
- Title: Subtitle
- Sex Differences in Outcomes of Late-Window Endovascular Stroke Therapy
- Creators
- Mohamad Abdalkader - Boston Medical CenterShen Ning - Boston Medical CenterMudassir Farooqui - University of IowaMuhammad M Qureshi - Boston Medical CenterDiogo C Haussen - Grady Memorial HospitalDaniel Strbian - Helsinki University HospitalSimon Nagel - Klinikum LudwigshafenJelle Demeestere - KU LeuvenVolker Puetz - University Hospital Carl Gustav CarusMahmoud H Mohammaden - Grady Memorial HospitalMarta Olive Gadea - Department of Neurology, Hospital Vall d'Hebron, Spain (M.O.G., F.R., M.R.)Simon Winzer - University Hospital Carl Gustav CarusHiroshi Yamagami - Osaka National HospitalKanta Tanaka - National Cerebral and Cardiovascular CenterJoão Pedro Marto - Centro Hospitalar de Lisboa OcidentalLiisa Tomppo - Helsinki University HospitalHilde Henon - Université de LilleSunil A Sheth - The University of Texas Health Science Center at HoustonSantiago Ortega-Gutierrez - Department of Neurology, University of Iowa (S.O.-G., M.F.)Nicolas Martinez-Majander - Helsinki University HospitalFrancois Caparros - Université de LilleRobin Lemmens - KU LeuvenAnne Dusart - Hôpital Civil de CharleroiFlavio Bellante - Hôpital Civil de CharleroiSyed F Zaidi - University of ToledoJames E Siegler - University of ChicagoStefania Nannoni - University of CambridgeJohannes Kaesmacher - University Hospital of BernTomas Dobrocky - University Hospital of BernSergio Salazar-Marioni - The University of Texas Health Science CenterPekka Virtanen - Helsinki University HospitalLieselotte Vandewalle - KU LeuvenAnke Wouters - KU LeuvenJessica Jesser - University Hospital HeidelbergRita Ventura - Hospital de Egas MonizAlicia C Castonguay - University of ToledoKazutaka Uchida - Hyogo UniversityAjit S Puri - Memorial Medical CenterHesham E Masoud - State University of New YorkPiers Klein - Boston Medical CenterZain Mansoor - Boston Medical CenterJenny Bui - Boston Medical CenterMatthew Kang - Boston Medical CenterAdnan Mujanovic - University Hospital of BernFederica Rizzo - Vall d'Hebron Hospital UniversitariTatu Kokkonen - Helsinki University HospitalJoão Nuno Ramos - Hospital de Egas MonizDavide Strambo - University of LausannePatrik Michel - University of LausanneMarkus A Möhlenbruch - Heidelberg UniversityEugene Lin - Mercy St. Vincent Medical CenterDaniel P O Kaiser - University Hospital Carl Gustav CarusShinichi Yoshimura - Hyogo UniversityNobuyuki Sakai - Kobe City Medical Center General HospitalCharlotte Cordonnier - Université de LillePeter A Ringleb - University Hospital HeidelbergDaniel Roy - Interventional Neuroradiology, CHU Montreal, Canada (D.R., J.R.)Osama O Zaidat - Mercy St. Vincent Medical CenterUrs Fischer - University Hospital of BaselMarc Ribo - Vall d'Hebron Hospital UniversitariJean Raymond - Interventional Neuroradiology, CHU Montreal, Canada (D.R., J.R.)Raul G Nogueira - Grady Memorial HospitalThanh N Nguyen - Boston Medical Center
- Resource Type
- Journal article
- Publication Details
- Stroke (1970), Vol.55(2), pp.278-287
- DOI
- 10.1161/STROKEAHA.123.045015
- PMID
- 38252759
- NLM abbreviation
- Stroke
- ISSN
- 0039-2499
- eISSN
- 1524-4628
- Language
- English
- Date published
- 02/2024
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984548466802771
Metrics
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