Journal article
Sex Differences in Severe Pulmonary Emphysema
American journal of respiratory and critical care medicine, Vol.176(3), pp.243-252
08/01/2007
DOI: 10.1164/rccm.200606-828OC
PMCID: PMC1994221
PMID: 17431226
Abstract
Rationale
: Limited data on sex differences in advanced COPD are available.
Objectives
: To compare male and female emphysema patients with severe disease.
Methods
: One thousand fifty-three patients (38.8% female) evaluated for lung volume reduction surgery as part of the National Emphysema Treatment Trial were analyzed.
Measurements and Main Results
: Detailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity and distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size and thickness was determined by histological analyses of resected tissue. Women were younger and exhibited a lower body mass index (BMI), shorter smoking history, less severe airflow obstruction, lower D
l
co
and arterial P
o
2
, higher arterial P
co
2
, shorter six-minute walk distance, and lower maximal wattage during oxygen-supplemented cycle ergometry. For a given FEV
1
% predicted, age, number of pack-years, and proportion of emphysema, women experienced greater dyspnea, higher modified BODE, more depression, lower SF-36 mental component score, and lower quality of well-being. Overall emphysema was less severe in women, with the difference from men most evident in the outer peel of the lung. Females had thicker small airway walls relative to luminal perimeters.
Conclusions
: In patients with severe COPD, women, relative to men, exhibit anatomically smaller airway lumens with disproportionately thicker airway walls, and emphysema that is less extensive and characterized by smaller hole size and less peripheral involvement.
Details
- Title: Subtitle
- Sex Differences in Severe Pulmonary Emphysema
- Creators
- Fernando J Martinez - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganJeffrey L Curtis - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganFrank Sciurba - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganJeanette Mumford - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganNicholas D Giardino - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganGail Weinmann - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganElla Kazerooni - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganSusan Murray - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganGerard J Criner - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganDonald D Sin - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganJames Hogg - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganAndrew L Ries - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganMeiLan Han - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganAlfred P Fishman - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganBarry Make - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganEric A Hoffman - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganZab Mohsenifar - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MichiganRobert Wise - University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.176(3), pp.243-252
- DOI
- 10.1164/rccm.200606-828OC
- PMID
- 17431226
- PMCID
- PMC1994221
- NLM abbreviation
- Am J Respir Crit Care Med
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Publisher
- American Thoracic Society
- Language
- English
- Date published
- 08/01/2007
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051703002771
Metrics
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