Sex-Related Differences in Outcomes of Left Atrial Appendage Occlusion Device Placement

Shafaqat Ali; Sanchit Duhan; Irisha Badu; Manoj Kumar; Thannon Alsaeed; Faryal Farooq; Bijeta Keisham; Abdul Rasheed Bahar; Lalitsiri Atti; Pramod Kumar Ponna; Michael Sewell; Vijaywant Brar; Pratik Agrawal; Tarek Helmy; Zain Ul Abideen Asad; Paari Dominic

doi:10.1111/pace.70152

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Sex-Related Differences in Outcomes of Left Atrial Appendage Occlusion Device Placement

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Sex-Related Differences in Outcomes of Left Atrial Appendage Occlusion Device Placement

Shafaqat Ali, Sanchit Duhan, Irisha Badu, Manoj Kumar, Thannon Alsaeed, Faryal Farooq, Bijeta Keisham, Abdul Rasheed Bahar, Lalitsiri Atti, Pramod Kumar Ponna, …

Pacing and clinical electrophysiology, 7803944

02/03/2026

DOI: 10.1111/pace.70152

PMID: 41631647

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Abstract

Background: Atrial fibrillation (AF) is associated with profound morbidity and mortality, including a fivefold increase in stroke risk. Left atrial appendage occlusion (LAAO) devices have emerged as an alternative approach to anticoagulation in patients with elevated bleeding risk and/or have contraindications to anticoagulation. However, females have been underrepresented in PROTECT & PREVAIL landmark trials supporting LAAO use. We aim to compare gender differences in outcomes of LAAO occlusive devices. Methods: The national readmission database (2016-2020) was utilized to identify hospitalizations for LAAO placement. Cohorts were stratified by gender as males and females. A propensity score matching (PSM) model matched both cohorts. Pearson's x2 test was applied to the matched cohorts to compare outcomes. Results: Among 89,552 hospitalizations for LAAO placement, 41.3% of procedures were performed in females. Females were found to have a lower prevalence of co-morbidities such as diabetes, hypertension, hyperlipidemia and CKD [p < 0.001]. Conclusion: In patients with hospitalizations for LAAO device placement, we observed a higher risk of net adverse events and mortality in females following the procedure compared to males. Prospective trials are warranted to identify and stratify the at-risk population with extensive preprocedural evaluation and determine ways to mitigate the sex-related disparities in clinical outcomes following the LAAO procedure.

Engineering

Technology

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Engineering, Biomedical

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Sex-Related Differences in Outcomes of Left Atrial Appendage Occlusion Device Placement
Creators: Shafaqat Ali - Louisiana State University in Shreveport
Sanchit Duhan - Carle Foundation Hospital
Irisha Badu - Onslow Memorial Hospital
Manoj Kumar - John H. Stroger, Jr. Hospital of Cook County
Thannon Alsaeed - Louisiana State University in Shreveport
Faryal Farooq - Allama Iqbal Medical College
Bijeta Keisham - Weifang Medical University
Abdul Rasheed Bahar - Wayne State University
Lalitsiri Atti - Sparrow Health System
Pramod Kumar Ponna - Louisiana State University in Shreveport
Michael Sewell - Louisiana State University in Shreveport
Vijaywant Brar - Sparrow Health System
Pratik Agrawal - Louisiana State University in Shreveport
Tarek Helmy - Louisiana State University in Shreveport
Zain Ul Abideen Asad - University of Oklahoma Medical Center
Paari Dominic - University of Iowa
Resource Type: Journal article
Publication Details: Pacing and clinical electrophysiology, 7803944
DOI: 10.1111/pace.70152
PMID: 41631647
NLM abbreviation: Pacing Clin Electrophysiol
ISSN: 0147-8389
eISSN: 1540-8159
Publisher: Wiley
Number of pages: 10
Language: English
Electronic publication date: 02/03/2026
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9985139493802771

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