Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson’s Disease

Marina Picillo; David-Erick LaFontant; Susan Bressman; Chelsea Caspell-Garcia; Christopher Coffey; Hyunkeun Ryan Cho; Elliot L Burghardt; Nabila Dahodwala; Rachel Saunders-Pullman; Caroline M Tanner; Amy W Amara; Parkinson’s Progression Markers Initiative

doi:10.3233/JPD-212892

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Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson’s Disease

Journal article

Open access

Peer reviewed

Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson’s Disease

Marina Picillo, David-Erick LaFontant, Susan Bressman, Chelsea Caspell-Garcia, Christopher Coffey, Hyunkeun Ryan Cho, Elliot L Burghardt, Nabila Dahodwala, Rachel Saunders-Pullman, Caroline M Tanner, …

Journal of Parkinson's disease, Vol.12(1), pp.421-436

01/01/2022

DOI: 10.3233/JPD-212892

PMCID: PMC8842783

PMID: 34744052

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Abstract

Background: Investigation of sex-related motor and non-motor differences and biological markers in Parkinson’s disease (PD) may improve precision medicine approach. Objective: To examine sex-related longitudinal changes in motor and non-motor features and biologic biomarkers in early PD. Methods: We compared 5-year longitudinal changes in de novo, untreated PD men and women (at baseline N = 423; 65.5%male) of the Parkinson’s Progression Markers Initiative (PPMI), assessing motor and non-motor manifestations of disease; and biologic measures in cerebrospinal fluid (CSF) and dopamine transporter deficit on DaTscanTM uptake. Results: Men experienced greater longitudinal decline in self-reported motor (p < 0.001) and non-motor (p = 0.009) aspects of experiences of daily living, such that men had a yearly increase in MDS-UPDRS part II by a multiplicative factor of 1.27 compared to women at 0.7, while men had a yearly increase in MDS-UPDRS part I by a multiplicative factor of 0.98, compared to women at 0.67. Compared to women, men had more longitudinal progression in clinician-assessed motor features in the ON medication state (p = 0.010) and required higher dopaminergic medication dosages over time (p = 0.014). Time to reach specific disease milestones and longitudinal changes in CSF biomarkers and DaTscanTM uptake were not different by sex. Conclusion: Men showed higher self-assessed motor and non-motor burden of disease, with possible contributions from suboptimal dopaminergic therapeutic response in men. However, motor features of disease evaluated with clinician-based scales in the OFF medication state, as well as biological biomarkers do not show specific sex-related progression patterns.

Biomarkers

Neurodegenerative Diseases

Parkinsons Disease

Cerebrospinal fluid

Dopamine receptors

Dopamine transporter

Movement disorders

Parkinson's disease

Precision medicine

Sex

Women

Details

Title: Subtitle: Sex-Related Longitudinal Change of Motor, Non-Motor, and Biological Features in Early Parkinson’s Disease
Creators: Marina Picillo
David-Erick LaFontant
Susan Bressman
Chelsea Caspell-Garcia
Christopher Coffey
Hyunkeun Ryan Cho
Elliot L Burghardt
Nabila Dahodwala
Rachel Saunders-Pullman
Caroline M Tanner
Amy W Amara
Parkinson’s Progression Markers Initiative
Resource Type: Journal article
Publication Details: Journal of Parkinson's disease, Vol.12(1), pp.421-436
DOI: 10.3233/JPD-212892
PMID: 34744052
PMCID: PMC8842783
NLM abbreviation: J Parkinsons Dis
ISSN: 1877-7171
eISSN: 1877-718X
Publisher: IOS Press BV
Language: English
Date published: 01/01/2022
Academic Unit: Biostatistics
Record Identifier: 9984214790802771

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