Journal article
Sex and cardiovascular disease status differences in attitudes and willingness to participate in clinical research studies/clinical trials
Trials, Vol.19(1), 300
05/30/2018
DOI: 10.1186/s13063-018-2667-7
PMCID: PMC5975677
PMID: 29843818
Abstract
Background:
While women are under-represented in research on cardiovascular disease (CVD), little is known about the attitudes of men and women with CVD regarding participation in clinical research studies/clinical trials.
Methods:
Patients with CVD (and/or risk factors) and patients with other chronic conditions from Iowa were recruited from a commercial panel. An on-line survey assessed willingness to participate (WTP) and other attitudes towards aspects of clinical research studies.
Results:
Based on 504 respondents, there were no differences in WTP in patients with CVD compared to patients with other chronic diseases. Across all respondents, men had 14% lower WTP (relative risk (RR) formen, 0.86, 95% CI, 0.72–1.02). Among patients with CVD, there was no significant difference in WTP betweenwomen (RR for women = 1) and men (RR for men, 0.96, 95% CI, 0.82–1.14).There were no significant differences based on sex or CVD status for attitudes on randomization, blinding,side effects, conflict of interest, experimental treatments or willingness to talk to one’s physician. Women had more favorable attitudes about participants being treated like“guinea pigs”(RR for men, 0.84, 95% CI, 0.73–0.98) and clinical trials being associated with terminally ill patients (RR for men, 0.93, 95% CI, 0.86–1.00).
Conclusions:
The findings reported here suggest that the observed lower levels of participation by women are due to factors other than a lower WTP or to women having more negative attitudes towards aspects of study participation.Patients with CVD have similar attitudes and WTP as patients with other chronic conditions.
Details
- Title: Subtitle
- Sex and cardiovascular disease status differences in attitudes and willingness to participate in clinical research studies/clinical trials
- Creators
- Thomas S Gruca - University of Iowa, MarketingWesley J. Hottel - University of IowaJanine Comstock - Cognizant ConsultingAnna Olson - OMDGary E. Rosenthal - University of Iowa, Institute for Clinical and Translational Science
- Resource Type
- Journal article
- Publication Details
- Trials, Vol.19(1), 300
- Publisher
- BMC
- DOI
- 10.1186/s13063-018-2667-7
- PMID
- 29843818
- PMCID
- PMC5975677
- ISSN
- 1745-6215
- eISSN
- 1745-6215
- Copyright
- © The Author(s). 2018
- Grant note
- This work was supported by the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program, grant U54TR001356. The CTSA program is led by the NIH’s National Center for Advancing Translational Sciences (NCATS). This publication’s contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Competing Interests: The authors declare that they have no competing interests.
- Language
- English
- Date published
- 05/30/2018
- Academic Unit
- Marketing; Hygienic Laboratory - Bdc; Internal Medicine
- Record Identifier
- 9983761185602771
Metrics
18 File views/ downloads
45 Record Views