Sex-based differences in the severity of radiation-induced arthrofibrosis

Samuel N Rodman; Paige N Kluz; Madeline R Hines; Rebecca E Oberley-Deegan; Mitchell C Coleman

doi:10.1002/jor.25297

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Sex-based differences in the severity of radiation-induced arthrofibrosis

Journal article

Open access

Peer reviewed

Sex-based differences in the severity of radiation-induced arthrofibrosis

Samuel N Rodman, Paige N Kluz, Madeline R Hines, Rebecca E Oberley-Deegan and Mitchell C Coleman

Journal of orthopaedic research, Vol.40(11), pp.2586-2596

11/2022

DOI: 10.1002/jor.25297

PMCID: PMC9365890

PMID: 35148568

Appears in UI Libraries Support Open Access

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Abstract

As cancer survivorship increases, so does the number of patients that suffer from the late effects of radiation therapy. This includes arthrofibrosis, the development of stiff joints near the field of radiation. Previous reports have concentrated on skin fibrosis around the joint but largely ignored the deeper tissues of the joint. We hypothesized that fat, muscle, and the joint tissues themselves would play a more significant role in joint contracture after radiation than the skin surrounding the joint. To address this hypothesis, we irradiated the right hind flanks of mice with fractionated and unfractionated dose schedules, then monitored the mice for 3 months postradiotherapy. Mice were euthanized and physiological indications of arthrofibrosis including limb contracture and joint resting position were assessed. Stifle (knee) joints demonstrated significant arthrofibrosis, but none was observed in the hock (ankle) joints. During these studies, we were surprised to find that male and female mice showed a significantly different response to radiation injury. Female mice developed more injuries, had significantly worse contracture, and showed a greater difference in the expression of all markers studied. These results suggest that women undergoing radiation therapy might be at significantly greater risk for developing arthrofibrosis and may require specific adjustments to their care.

Orthopedics

Life Sciences & Biomedicine

Science & Technology

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Details

Title: Subtitle: Sex-based differences in the severity of radiation-induced arthrofibrosis
Creators: Samuel N Rodman - University of Iowa
Paige N Kluz - University of Iowa
Madeline R Hines - University of Iowa
Rebecca E Oberley-Deegan - Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE USA
Mitchell C Coleman - University of Iowa
Resource Type: Journal article
Publication Details: Journal of orthopaedic research, Vol.40(11), pp.2586-2596
DOI: 10.1002/jor.25297
PMID: 35148568
PMCID: PMC9365890
NLM abbreviation: J Orthop Res
ISSN: 0736-0266
eISSN: 1554-527X
Publisher: Wiley
Number of pages: 11
Grant note: AR070914 / National Institute of Arthritis and Musculoskeletal and Skin Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
Language: English
Electronic publication date: 02/21/2022
Date published: 11/2022
Academic Unit: Orthopedics and Rehabilitation; Radiation Oncology
Record Identifier: 9984242429802771

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