Journal article
Sex differences and central protective effect of 17β-estradiol in the development of aldosterone/NaCl-induced hypertension
American journal of physiology. Heart and circulatory physiology, Vol.296(5), pp.H1577-H1585
05/2009
DOI: 10.1152/ajpheart.01255.2008
PMCID: PMC2685359
PMID: 19270192
Abstract
The present study tested the hypotheses that male and female rats respond differently to subcutaneous infusions of aldosterone (Aldo; 1.8 μg·kg
−1
·h
−1
, 1% NaCl to drink; 28 days) and that central estrogen plays a protective role against the development of hypertension. In rats with blood pressure (BP) and heart rate (HR) measured by Data Sciences International telemetry, chronic Aldo/NaCl treatment induced a greater increase in BP in males (Δ25.4 ± 2.4 mmHg) than in females (Δ7.1 ± 2.2 mmHg). Gonadectomy augmented Aldo/NaCl-induced hypertension in females (Δ18.2 ± 2.0 mmHg) but had no effect in males (Δ23.1 ± 2.9 mmHg). Immunohistochemistry for Fra-like activity was higher in the paraventricular nucleus of intact males, castrated males, and ovariectomized (OVX) females compared with intact females after 28 days of Aldo/NaCl treatment. In intact males, central 17β-estradiol (E
2
) inhibited the Aldo/NaCl increase in BP (Δ10.5 ± 0.8) compared with that in central vehicle plus systemic Aldo/NaCl (Δ26.1 ± 2.5 mmHg) rats. Combined administration of E
2
and estrogen receptor antagonist ICI182780 (ICI) blocked the protective effect of E
2
(Δ23.2 ± 2.4 mmHg). In intact females central, but not peripheral, infusions of ICI augmented the Aldo/NaCl (Δ20.4 ± 1.8 mmHg) BP increase. Finally, ganglionic blockade after Aldo infusions resulted in a smaller reduction in BP in intact females (−23.9 ± 2.5 mmHg) and in central estrogen-treated males (−30.2 ± 1.0 mmHg) compared with other groups (intact males, −39.3 ± 3.4; castrated males, −41.8 ± 1.9; intact males with central E
2
+ ICI, −42.3 ± 2.1; OVX females, −40.3 ± 3.3; and intact females with central ICI, −39.1 ± 1.3 mmHg). Chronic Aldo infusion produced increases in NaCl intake and decreases in HR that were both similar in all groups. Taken together, the results indicate that central estrogen plays a protective role in the development of Aldo/NaCl-induced hypertension and that this may result from reduced sympathetic outflow.
Details
- Title: Subtitle
- Sex differences and central protective effect of 17β-estradiol in the development of aldosterone/NaCl-induced hypertension
- Creators
- Baojian Xue - Departments of Psychology, Pharmacology, and Integrative Physiology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Physiology, University of Arizona, Tucson, ArizonaDaniel Badaue-Passos - Departments of Psychology, Pharmacology, and Integrative Physiology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Physiology, University of Arizona, Tucson, ArizonaFang Guo - Departments of Psychology, Pharmacology, and Integrative Physiology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Physiology, University of Arizona, Tucson, ArizonaCelso E Gomez-Sanchez - Departments of Psychology, Pharmacology, and Integrative Physiology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Physiology, University of Arizona, Tucson, ArizonaMeredith Hay - Departments of Psychology, Pharmacology, and Integrative Physiology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Physiology, University of Arizona, Tucson, ArizonaAlan Kim Johnson - Departments of Psychology, Pharmacology, and Integrative Physiology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa; Division of Endocrinology, G.V. (Sonny) Montgomery VA Medical Center, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Physiology, University of Arizona, Tucson, Arizona
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.296(5), pp.H1577-H1585
- DOI
- 10.1152/ajpheart.01255.2008
- PMID
- 19270192
- PMCID
- PMC2685359
- NLM abbreviation
- Am J Physiol Heart Circ Physiol
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Publisher
- American Physiological Society
- Language
- English
- Date published
- 05/2009
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health, Sport, and Human Physiology
- Record Identifier
- 9984213268402771
Metrics
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