Journal article
Sex differences in cardiovascular adaptations in recreational marathon runners
European journal of applied physiology, Vol.121(12), pp.3459-3472
12/2021
DOI: 10.1007/s00421-021-04806-1
PMID: 34515867
Abstract
There are well-established sex differences in central hemodynamic and cardiac adaptations to endurance exercise; however, controversial evidence suggests that excessive endurance exercise may be related to detrimental cardiovascular adaptations in marathoners.
To examine left ventricle (LV) structure, LV function, 24-h central hemodynamics and ventricular-vascular coupling in male and female marathoners and recreationally active adults.
52 marathoners (41 ± 5 years, n = 28 female, completed 6 ± 1 marathons/3 years) and 49 recreationally active controls (42 ± 5 years, n = 25 female) participated in the study. Three-Dimensional Echocardiography (3DE) was used to measure LV mass index and LV longitudinal (LS) circumferential (CS), area (AS), and radial strain (RS). An ambulatory blood pressure (BP) cuff was used to measure 24-h central hemodynamics (BP, pulse wave velocity, PWV, wave reflection index, RIx). Hemodynamic and 3DE measures were combined to derive the ratio of arterial elastance (Ea) to ventricular elastance (Elv) as a global measure of ventricular-vascular coupling.
There were no sex or group differences in LS, CS, AS, and RS (p > 0.05). Females marathoners had similar aortic BP (116 ± 9 vs. 113 ± 1 mmHg), and PWV (5.9 ± 0.5 vs. 5.9 ± 1.1 m/s) compared to female controls but lower aSBP (116 ± 9 vs. 131 ± 10 mmHg) and PWV (5.9 ± 0.5 vs. 6.2 ± 0.5 m/s) compared to male marathoners (p < 0.05). Female marathoners had lower Ea/Elv than female controls (0.67 ± 0.20 vs. 0.93 ± 0.36) and male marathoners (0.67 ± 0.20 vs. 0.85 ± 0.42, p < 0.05).
Women that have completed multiple marathons do not have reduced LV function or increased aortic stiffness and may have better ventricular-vascular coupling compared to male marathoners and their female untrained counterparts.
Details
- Title: Subtitle
- Sex differences in cardiovascular adaptations in recreational marathon runners
- Creators
- Jacqueline A Augustine - Syracuse UniversityWesley K Lefferts - Syracuse UniversityJacob P DeBlois - Syracuse UniversityTiago V Barreira - Syracuse UniversityBeth A Taylor - University of ConnecticutKan Liu - University of IowaKevin S Heffernan - Syracuse University
- Resource Type
- Journal article
- Publication Details
- European journal of applied physiology, Vol.121(12), pp.3459-3472
- DOI
- 10.1007/s00421-021-04806-1
- PMID
- 34515867
- ISSN
- 1439-6319
- eISSN
- 1439-6327
- Grant note
- School of Education Grant Competition / Syracuse University Sydney Young Research Award / Syracuse University Love of Learning Award / Phi Kappa Phi
- Language
- English
- Date published
- 12/2021
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318715602771
Metrics
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