Journal article
Sex differences in endothelial function in chronic kidney disease
American journal of physiology. Renal physiology, Vol.319(1), pp.F33-F40
07/01/2020
DOI: 10.1152/ajprenal.00156.2020
PMCID: PMC7468834
PMID: 32421350
Abstract
Vascular dysfunction plays an important role in the etiology of chronic kidney disease (CKD) and is associated with cardiovascular diseases. Sex differences in vascular function arc common in clinical and nonclinical populations. However, no data exist in individuals with CKD. The present study tested the hypothesis that sex and/or aging differences exist in vascular function in patients with CKD. Endothelium-dependent dilation (EDD: measured via brachial artery flow-mediated dilation) and endothelium-independent dilation (EID; measured via nitroglycerin-mediated dilation) were assessed. Analyses were adjusted for several variables that could influence vascular function (diabetes, cardiovascular disease, and blood pressure). Women, in general, had higher EDD values than men (6.5 +/- 4.9% vs. 4.4 +/- 3.4%); however, EID did not differ among these groups. In younger men and women (<55 yr old), EDD and EID were higher (P < 0.05) than their older (>= 55 yr old) counterparts (EDD: 7.0 +/- 4.1% vs. 4.4 +/- 3.8% and EID: 24.0 +/- 9.6% vs. 18.3 +/- 9.2%). Additionally, younger women exhibited higher (P < 0.05) EDD and EID compared with younger men (EDD: 95 +/- 6.4% vs. 5.1 +/- 3.8%. P = 0.01, and EID: 24.0 +/- 9.6% vs. 18.3 +/- 9.2%). No differences in EDD and ED were present between older men and women with CKD. Diabetes independently predicted lower FAD but not EDD in men and women. Blood pressure and cardiovascular disease did not predict EDD or ED/ This is the first study to show significant sex differences in vascular function. Moreover, these differences are evident between younger men and women with CKD but are abolished with age. Additional studies are needed to better understand the mechanisms that may underlie sex differences in vascular dysfunction with CKD.
Details
- Title: Subtitle
- Sex differences in endothelial function in chronic kidney disease
- Creators
- Nicholas T. Kruse - University of IowaZhiying You - University of Colorado DenverKerrie Moreau - University of Colorado Anschutz Medical CampusJessica Kendrick - University of Colorado DenverDiana Jalal - Iowa City VA Health Care System
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Renal physiology, Vol.319(1), pp.F33-F40
- Publisher
- Amer Physiological Soc
- DOI
- 10.1152/ajprenal.00156.2020
- PMID
- 32421350
- PMCID
- PMC7468834
- ISSN
- 1931-857X
- eISSN
- 1522-1466
- Number of pages
- 8
- Grant note
- K23DK088833; K23DK087859 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Carver College of Medicine
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984360046402771
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